Case Western Reserve University School of Medicine (CWRU SOM) has provided integrated MD-PhD training since 1956 with many distinguished alumni, including two Nobel laureates. The NIH-funded CWRU Medical Scientist Training Program (MSTP) was started in 1975 (T32 GM07250) and has 107 current students. Research and clinical training occurs at CWRU and affiliated institutions (University Hospitals Cleveland Medical Center, Cleveland Clinic, MetroHealth Medical Center and the Louis Stokes Veteran?s Administration Medical Center). These sites are well equipped for cutting edge research and state of the art clinical training. The CWRU MSTP curriculum integrates scientific and clinical instruction in all three phases: both PhD and MD course work during the first two years, substantial personalized clinical instruction as well as research during the PhD years, and clinical clerkships, clinical electives and research electives in the final phase. PhD mentors provide individualized research training. Active mentors are well supported by NIH research grants or other funding sources; they also have established research training track records or, in the case of Initial Mentors, will be paired with a Senior Mentor to insure effective mentoring of trainees and to develop the mentoring skills of new trainers. Criteria for acceptance of MSTP students include superior academic performance and evidence of strong commitment and skills for research. Acceptance by the MSTP automatically admits a student to the SOM and any of the 14 MSTP-affiliated PhD programs. All CWRU MSTP students receive full financial support for stipend, tuition and health fees for all phases of the program (8.3 years mean duration), and the program provides laptop computers and travel awards for students to attend national research meetings. Numerous MSTP-specific program activities supplement the PhD and MD curricula. The program emphasizes development of leadership skills through student governance, faculty mentoring, and student-led program activities.

Public Health Relevance

The CWRU Medical Scientist Training Program integrates research and clinical training of physician scientists in basic and translational biomedical sciences. Training in these areas can then be applied to a wide range of basic, translational and clinical research. Our mission is to train MD-PhD students for productive careers in biomedical research to fill the national need for future physician-scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
3T32GM007250-45S1
Application #
10183382
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Maas, Stefan
Project Start
1975-07-01
Project End
2021-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
45
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Tanenbaum, Joseph E; Kha, Stephanie T; Benzel, Edward C et al. (2018) The association of inflammatory bowel disease and immediate postoperative outcomes following lumbar fusion. Spine J 18:1157-1165
Elitt, Matthew S; Shick, H Elizabeth; Madhavan, Mayur et al. (2018) Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease. Stem Cell Reports 11:711-726
Sarvestani, Samaneh K; Signs, Steven A; Lefebvre, Veronique et al. (2018) Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids. Oncotarget 9:28717-28730
Hickman, DaShawn A; Pawlowski, Christa L; Shevitz, Andrew et al. (2018) Intravenous synthetic platelet (SynthoPlate) nanoconstructs reduce bleeding and improve 'golden hour' survival in a porcine model of traumatic arterial hemorrhage. Sci Rep 8:3118
Luu, Jennings; Palczewski, Krzysztof (2018) Human aging and disease: Lessons from age-related macular degeneration. Proc Natl Acad Sci U S A 115:2866-2872
Yang, Jie; Liu, Zhonghua; Wang, Chuanping et al. (2018) Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A 115:6792-6797
Mamidi, Ranganath; Li, Jiayang; Doh, Chang Yoon et al. (2018) Impact of the Myosin Modulator Mavacamten on Force Generation and Cross-Bridge Behavior in a Murine Model of Hypercontractility. J Am Heart Assoc 7:e009627
Benson, Bryan L; Li, Lucy; Myers, Jay T et al. (2018) Biomimetic post-capillary venule expansions for leukocyte adhesion studies. Sci Rep 8:9328
Borton, Anna Henry; Benson, Bryan L; Neilson, Lee E et al. (2018) Aryl Hydrocarbon Receptor Nuclear Translocator in Vascular Smooth Muscle Cells Is Required for Optimal Peripheral Perfusion Recovery. J Am Heart Assoc 7:
Zhou, Hua-Lin; Stomberski, Colin T; Stamler, Jonathan S (2018) Cross Talk Between S-Nitrosylation and Phosphorylation Involving Kinases and Nitrosylases. Circ Res 122:1485-1487

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