The goal of our Medical Scientist Training Program is to train individuals who will be both outstanding biomedical scientists and data-driven physicians, pioneering major advances in medical practice through research. This goal is intimately aligned with a central mission of The University of Virginia SOM: To conduct outstanding biomedical research and to pioneer developments in the practice of medicine. Importantly, and in keeping with the broader career training vision of the NIH for trainees, our long-term goals for our graduates include training not only future academic researchers, educators, and administrators but also leaders in other non-traditional careers in the private or public sector that advance our understanding of human disease, help develop more effective medical therapies, or affect policy in these areas. The impressive successes and wide-ranging professional avenues that our alumni have pursued is testimony to the positive outcomes of this philosophy. We have developed the physical facilities and infra-structural support necessary to allow our faculty to achieve international prominence and to make discoveries that advance our understanding of key cellular processes and mechanisms of disease. In this proposal, we enumerate our successes and detail our plans to further improve our training of the next generation of physician-scientists.

Public Health Relevance

Bridging the gap between biomedical discoveries and clinical practice in the United States and elsewhere is challenging. Scientists and doctors often have surprisingly distinct types of professional training in how to think and communicate about their work. We are proposing in this application to continue to train physician-scientists in both rigorous experimental science and clinical medicine, allowing them to interact with both worlds, imbue their own research programs with medically relevant themes, and push new discoveries forward to benefit public health.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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NIGMS Initial Review Group (TWD)
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Gindhart, Joseph G
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University of Virginia
Schools of Medicine
United States
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Sharma, Ashish K; Charles, Eric J; Zhao, Yunge et al. (2018) Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 315:L301-L312
Adamson, Samantha E; Montgomery, Garren; Seaman, Scott A et al. (2018) Myeloid P2Y2 receptor promotes acute inflammation but is dispensable for chronic high-fat diet-induced metabolic dysfunction. Purinergic Signal 14:19-26
Harbom, Lise J; Michel, Nadine; McConnell, Michael J (2018) Single-cell analysis of diversity in human stem cell-derived neurons. Cell Tissue Res 371:171-179
Bolte, Ashley C; Lukens, John R (2018) Th17 Cells in Parkinson's Disease: The Bane of the Midbrain. Cell Stem Cell 23:5-6
Cortina, George A; Kasson, Peter M (2018) Predicting allostery and microbial drug resistance with molecular simulations. Curr Opin Struct Biol 52:80-86
Cronk, James C; Filiano, Anthony J; Louveau, Antoine et al. (2018) Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia. J Exp Med 215:1627-1647
Newman, Alexandra Ac; Baylis, Richard A; Hess, Daniel L et al. (2018) Irradiation abolishes smooth muscle investment into vascular lesions in specific vascular beds. JCI Insight 3:
Narahari, Adishesh K; Charles, Eric J; Mehaffey, J Hunter et al. (2018) Cardiothoracic surgery training grants provide protected research time vital to the development of academic surgeons. J Thorac Cardiovasc Surg 155:2050-2056
Khalil, Shadi; Delehanty, Lorrie; Grado, Stephen et al. (2018) Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor. J Exp Med 215:661-679
Stevens, Jacqueline S; Gray, Mary C; Morisseau, Christophe et al. (2018) Endocervical and Neutrophil Lipoxygenases Coordinate Neutrophil Transepithelial Migration to Neisseria gonorrhoeae. J Infect Dis 218:1663-1674

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