This application seeks support for continuing a long-standing and successful predoctoral training program in Cellular and Molecular Biology. The current and proposed program supports 16 students. The program has been repeatedly updated over the past 35 years and includes a curriculum that educates our trainees broadly and deeply in the rapidly evolving areas of cellular and molecular biology. It encourages students to apply quantitative and multidisciplinary approaches to biological problems. The Graduate Field of Biochemistry, Molecular and Cell Biology, which administers this training grant, includes 51 faculty who represent 11 undergraduate departments and a broad array of disciplines and biological systems. The faculty not only brings unique perspectives to training students, but also provide the multidisciplinary tools that contribute so effectively to solving biological problems. Excellent facilities are available at Cornell, providing modern research laboratories and state-of-the-art core services. Students admitted to the Program have undergraduate degrees in the biological or physical sciences. A comprehensive set of lecture and laboratory courses and laboratory rotations make up the first year of the Program, followed by research, additional courses, and an obligatory teaching requirement. These first two years of the training program ensure all students have a solid background in molecular and cell biology and in quantitative methods regardless of their diverse undergraduate training. The teaching requirement ensures the students have exposure to basic teaching skills that should serve them well in many of their career options. The curriculum also includes a novel component designed to expose our students to the broad landscape of career options. In addition to their major subject, trainees select a minor graduate subject to broaden their training. The remaining time is devoted mainly to research and continued training by attending and presenting seminars and interaction with faculty and postdoctoral fellows. Monitoring of students'progress continues through their complete tenure. The entire Field meets to assess the first year lab rotations and course performance, and a student's special committee meets yearly following the student's research seminar to assess progress.

Public Health Relevance

The well-established but continuously evolving discipline of Cellular and Molecular Biology will continue to be the scientific foundation for advances in medicine for decades to come. Our graduate training program has been training students in both traditional and interdisciplinary approaches to solving fundamental biological problems for 35 years. The support provided by NIH for this training program is critical to Outcomes are very good with high proportion of students in faculty positions continue training students in this fundamental discipline that is at the core of medical breakthroughs.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM007273-36
Application #
7849805
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Preusch, Peter C
Project Start
1975-07-01
Project End
2015-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
36
Fiscal Year
2010
Total Cost
$643,430
Indirect Cost
Name
Cornell University
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
872612445
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Beacham, Gwendolyn M; Partlow, Edward A; Lange, Jeffrey J et al. (2018) NECAPs are negative regulators of the AP2 clathrin adaptor complex. Elife 7:
Thomas, Laura L; Joiner, Aaron M N; Fromme, J Christopher (2018) The TRAPPIII complex activates the GTPase Ypt1 (Rab1) in the secretory pathway. J Cell Biol 217:283-298
Halaby, Steve L; Fromme, J Christopher (2018) The HUS box is required for allosteric regulation of the Sec7 Arf-GEF. J Biol Chem 293:6682-6691
Liu, Yi; Cussiol, José Renato; Dibitetto, Diego et al. (2017) TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9. J Cell Biol 216:623-639
Siegenthaler, Kevin D; Pareja, Kristeen A; Wang, Jie et al. (2017) An unexpected role for the yeast nucleotide exchange factor Sil1 as a reductant acting on the molecular chaperone BiP. Elife 6:
Liberti, Maria V; Dai, Ziwei; Wardell, Suzanne E et al. (2017) A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab 26:648-659.e8
Wang, Alex B; Zhang, Ying V; Tumbar, Tudorita (2017) Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation. EMBO J 36:61-78
Pierpont, Timothy M; Lyndaker, Amy M; Anderson, Claire M et al. (2017) Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer. Cell Rep 21:1896-1909
Gustafson, Margaret A; Fromme, J Christopher (2017) Regulation of Arf activation occurs via distinct mechanisms at early and late Golgi compartments. Mol Biol Cell 28:3660-3671
Taylor, David H; McLean, Chelsea M; Wu, Warren L et al. (2016) Imprinted DNA methylation reconstituted at a non-imprinted locus. Epigenetics Chromatin 9:41

Showing the most recent 10 out of 124 publications