The U. Chicago Medical Scientist Training Program submits this renewal application to the National Institutes of Health to continue and expand into the next century its training of outstanding leaders in the biomedical field. We request funding for 48 MSTP positions, an increase of 4 from the currently recommended slots (44 recommended/36 funded). At the requested level of support, NIH funding will cover approximately 25% of the program's costs, the rest being provided by institutional resources. We plan to recruit matriculating classes of 12 students who are expected to graduate in 8 years. The Medical Scientist Training Program at the U. Chicago Pritzker School of Medicine has been in existence for 37 years with uninterrupted funding and a superb training record of academic physicians in leadership positions (including directorships of MSTPs at UCSF and Harvard). It has graduated 193 students who have published over 1500 papers. Currently 68 individuals are enrolled in the program including 6% URM and 30% women. In the last five years, 34 students graduated from the Program and 38 students entered it. Continuing in the tradition of its graduates, our current MSTP students have published extensively in top journals such as Nature, Science, Cell, Immunity, Journal of Biological Chemistry, and others. In this proposal we provide compelling and detailed evidence on the superb quality of our students and the rigorous training environment at Chicago which is uniquely configured to support interdisciplinary programs such as the MSTP. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007281-34
Application #
7449695
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Shapiro, Bert I
Project Start
1975-07-01
Project End
2010-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
34
Fiscal Year
2008
Total Cost
$1,838,678
Indirect Cost
Name
University of Chicago
Department
Pathology
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Zhao, Boxuan Simen; Roundtree, Ian A; He, Chuan (2018) Publisher Correction: Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Biol 19:808
Parameswaran, Ramya; Tian, Bozhi (2018) Rational Design of Semiconductor Nanostructures for Functional Subcellular Interfaces. Acc Chem Res 51:1014-1022
Chateau, Alice; Lunderberg, Justin Mark; Oh, So Young et al. (2018) Galactosylation of the Secondary Cell Wall Polysaccharide of Bacillus anthracis and Its Contribution to Anthrax Pathogenesis. J Bacteriol 200:
Banovich, Nicholas E; Li, Yang I; Raj, Anil et al. (2018) Impact of regulatory variation across human iPSCs and differentiated cells. Genome Res 28:122-131
Mandal, Malay; Maienschein-Cline, Mark; Maffucci, Patrick et al. (2018) BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis. Nat Commun 9:3888
Bershad, Anya K; Ruiz, Nicholas A; de Wit, Harriet (2018) Effects of Buprenorphine on Responses to Emotional Stimuli in Individuals with a Range of Mood Symptomatology. Int J Neuropsychopharmacol 21:120-127
Montefiori, Lindsey E; Sobreira, Debora R; Sakabe, Noboru J et al. (2018) A promoter interaction map for cardiovascular disease genetics. Elife 7:
Yang, Ying; Hsu, Phillip J; Chen, Yu-Sheng et al. (2018) Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism. Cell Res 28:616-624
Uddin, Sophia; Heald, Shannon L M; Van Hedger, Stephen C et al. (2018) Understanding environmental sounds in sentence context. Cognition 172:134-143
An, Ningfei; Khan, Saira; Imgruet, Molly K et al. (2018) Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS. Blood 131:2682-2697

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