The mission of the Medical Scientist Training Program (MSTP) of the Albert Einstein College of Medicine is to train physician-scientists who will become future leaders in biomedical and clinical research. The MSTP strives to recruit a diverse group of outstanding students. It provides them with rigorous integrate medical and research training that prepares them for careers as physician-scientists. Through a flexible and continously evolving curriculum that includes 1) specialized MSTP courses and 2) integration of graduate and medical school curriculum in the first 2 years, the students are guided through a program that can be tailored to meet their individual needs and interests. The progam seeks to provide the trainees with a solid foundation for careers as independent physician-scientists and to facilitate their placement into outstanding postgraduate training programs to facilitate the next step in their career progression. The training program has 3 phases. In the first 2 years students take an integrated combination of medical, graduate and MSTP-specific courses to provide the didactic foundation for their reseach and clinical training. They perform research rotations to assist them in choosing their thesis research lab. In the program's 2nd phase, they perform independent, original research under their mentor's guidance. They publish their discoveries in high quality peer-reviewed papers, and prepare and defend a PhD thesis. Participation in an evening, MSTP-run, ambulatory outpatient clinic allows them to build their clinical skills during the PhD phase of the program. In the final phase, they complete their clinical training on the wards. We are developing a longitudinal learning experience to foster rigor and reproducibility in the research performed by MSTP students. The admissions process seeks to identify individuals with the intelligence, curiosity, creativity, resilience, perseverence and enthusiam for science that is essential for future success in a research career. Currently, 103 trainees are in the program, 37% are woman and 25% are members of underrepresented minorities. We plan to expand the program to a steady state size of ~120-130 trainees by increasing the size of our entering class to 16. Since its inception in 1964, as one of the first three NIH funded MD-PhD training programs, 425 trainees have graduated. 346 have completed postgraduate training and published over 18,000 papers, an average of 53 papers per graduate. 74% have jobs at academic medical centers, research institutes, NIH or pharmaceutical companies. By various measures, the program graduates have achieved outstanding success in their chosen careers. They have advanced biomedical research and academic medicine. Based on the quality of our past accomplishments and the new developments in biomedical research, we propose to evolve the program, to further integrate graduate and medical training, and increase opportunities for involvement in clinical and translational research in order to prepare a future generation of physician-scientists who will be at the leading edge of biomedical research with the ultimate goal of improving human health and reducing the burden of disease.

Public Health Relevance

Physician-scientists perform a critical role at the interface between basic biomedical research and clinical medicine. This program will train a diverse group of outstanding students and prepare them to enter the biomedical research workforce as physician-scientists who will perform basic, translational, and clinical research. This research will lead to new treatments to prevent or cure disease and improve the health of all Americans.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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NIGMS Initial Review Group (TWD)
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Maas, Stefan
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Albert Einstein College of Medicine
United States
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Zamurrad, Sumaira; Hatch, Hayden A M; Drelon, Coralie et al. (2018) A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5. Cell Rep 22:2359-2369
Kerner-Rossi, Mallory; Gulinello, Maria; Walkley, Steven et al. (2018) Pathobiology of Christianson syndrome: Linking disrupted endosomal-lysosomal function with intellectual disability and sensory impairments. Neurobiol Learn Mem :
Carvajal, Luis A; Neriah, Daniela Ben; Senecal, Adrien et al. (2018) Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia. Sci Transl Med 10:
Schloss, Jennifer; Ali, Riyasat; Racine, Jeremy J et al. (2018) HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression. J Immunol 200:3353-3363
Zheng, Zengming; Wang, Zhou-Guang; Chen, Yu et al. (2018) Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration. J Cell Mol Med 22:3086-3096
Dowling, Samuel D; Macian, Fernando (2018) Autophagy and T cell metabolism. Cancer Lett 419:20-26
Tutucci, Evelina; Vera, Maria; Biswas, Jeetayu et al. (2018) An improved MS2 system for accurate reporting of the mRNA life cycle. Nat Methods 15:81-89
Rastogi, Deepa; Nico, John; Johnston, Andrew D et al. (2018) CDC42-related genes are upregulated in helper T cells from obese asthmatic children. J Allergy Clin Immunol 141:539-548.e7
Tu, Vincent; Yakubu, Rama; Weiss, Louis M (2018) Observations on bradyzoite biology. Microbes Infect 20:466-476
Mao, Serena P H; Park, Minji; Cabrera, Ramon M et al. (2018) Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth. Breast Cancer Res 20:131

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