We propose to continue a flexible interdisciplinary Graduate Training Program, currently in its 33rd year, designed to prepare exceptional students for productive research careers in Systems & Integrative Biology (SIB). Our Predoctoral Training Program trains graduate students to work towards understanding the operation of the nervous system, including education and research opportunities to identify and ameliorate many dysfunctional and disease conditions such as stroke, epilepsy, neurodegenerative disorders and addiction. This program is based in the Neuroscience Graduate Group (NGG), an interdepartmental group of 102 faculty members from 24 departments in 4 Schools of the University of Pennsylvania. Graduate education in the Life Sciences at Penn is based on such Graduate Groups. The Office of Biomedical Graduate Studies (BGS) ensures curricular development, quality control and uniform admission standards across all of these Graduate Groups. Direct management of the SIB Training Program is done by a five-person Executive Committee that sets and reviews policy and selects trainees. SIB Faculty membership is governed by three criteria: (1) expertise in a relevant field of study, (2) significant contributio to training, and (3) extramural funding to support trainees. Admission of students to Graduate Programs is decided by a BGS-wide admissions committee. Subsequent admission to the SIB Program is decided by its Executive Committee. Support for each trainee will encompass their first 21 months in graduate school. The Training Program will consist of two years of coursework plus at least two lab rotations. All students will take a yearly course on the responsible conduct of scientific research. Students will also receive training through seminars, journal clubs, annual retreats, scientific meetings, paper and poster presentations, and social events that encourage interactions. Successful completion of a comprehensive Candidacy examination marks the start of independent research toward the dissertation. Thesis research is conducted under the supervision of a faculty advisor and is monitored by a thesis committee and the NGG Academic Review Committee. The dissertation defense takes place when the thesis advisor and committee agree that the work is complete. Most graduates move on for advanced (postdoctoral) training and pursue an academic career. Based on the number of potential trainees, we request support for 12 predoctoral trainees per year for the next 5 years.

Public Health Relevance

This Predoctoral Training Program includes education and research opportunities to identify and ameliorate many dysfunctional and disease conditions, such as stroke, epilepsy, neurodegenerative disorders and addiction.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007517-38
Application #
8870365
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Maas, Stefan
Project Start
1978-07-01
Project End
2016-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
38
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Neurosciences
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kridsada, Kim; Niu, Jingwen; Haldipur, Parthiv et al. (2018) Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons. Cell Rep 23:2928-2941
Jackson, Dan P; Ting, Jenhao H; Pozniak, Paul D et al. (2018) Identification and characterization of two novel alternatively spliced E2F1 transcripts in the rat CNS. Mol Cell Neurosci 92:1-11
Hernandez-Fleming, Melissa; Rohrbach, Ethan W; Bashaw, Greg J (2017) Sema-1a Reverse Signaling Promotes Midline Crossing in Response to Secreted Semaphorins. Cell Rep 18:174-184
Fleming, Michael S; Li, Jian J; Ramos, Daniel et al. (2016) A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles. J Neurosci 36:10337-10355
Healey, Meghan L; Grossman, Murray (2016) Social Coordination in Older Adulthood: A Dual-Process Model. Exp Aging Res 42:112-7
Harris, J P; Struzyna, L A; Murphy, P L et al. (2016) Advanced biomaterial strategies to transplant preformed micro-tissue engineered neural networks into the brain. J Neural Eng 13:016019
Jensen, Brigid K; Monnerie, Hubert; Mannell, Maggie V et al. (2015) Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders. J Neuropathol Exp Neurol 74:1093-118
Christison-Lagay, Kate L; Gifford, Adam M; Cohen, Yale E (2015) Neural correlates of auditory scene analysis and perception. Int J Psychophysiol 95:238-245
Dumoulin, Michelle C; Aton, Sara J; Watson, Adam J et al. (2015) Extracellular signal-regulated kinase (ERK) activity during sleep consolidates cortical plasticity in vivo. Cereb Cortex 25:507-15
Carruthers, Isaac M; Laplagne, Diego A; Jaegle, Andrew et al. (2015) Emergence of invariant representation of vocalizations in the auditory cortex. J Neurophysiol 114:2726-40

Showing the most recent 10 out of 74 publications