The purpose of this Training Program is to educate students in the modern ideas and techniques of integrated biological function, using molecular biology and genetics, biochemistry, cell biology, pharmacology, membrane physics, protein structure, and computer modeling to elucidate how the activities of molecules and cells give rise to complex processes and behaviors in living organisms.
The aim i s to educate students broadly in both the philosophy and the technologies of modern physiological research, and to launch them into careers in teaching and research where they can contribute significantly to basic biological science per se and to human health. Students are sought with a bachelor's or master's degree in science, a firm background in mathematics and biology, and advanced undergraduate training in a least one area of cell biology, biochemistry, or physical science. The average time for completing the program is 5 years; students receive the Ph.D. degree from Yale University. The forty primary training faculty are drawn from a number of departments within Yale School of Medicine and are affiliated with Cellular & Molecular Physiology, the combined Cell Biology and Molecular Physiology Track or selected other departments. Because the majority of integrative processes in biological systems depend upon membrane function, the training faculty are focused in cellular and membrane research including i) Epithelial function; ii) Mechanisms of membrane transport; iii) Neuroscience including excitable membranes; iv) Protein synthesis and intracellular transport; and v) Protein structure-function. Three other groups are working in vi) Regulation and second messenger functions, vii) Muscle and molecular motors, and viii) Cardiovascular, metabolic, and exercise physiology In most of these groups, technical expertise spans organ physiology, membrane biophysics, biochemistry, and molecular biology and genetics, and protein structure. In addition to the training faculty and their laboratories, the facilities available to trainees include the more than 200 faculty in the interdepartmental Combined Program in the Biological and Biomedical Sciences (BBS) at Yale, as well as a abroad range of modern core facilities.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007527-28
Application #
6770113
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Cole, Alison E
Project Start
1982-07-01
Project End
2005-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
28
Fiscal Year
2004
Total Cost
$210,694
Indirect Cost
Name
Yale University
Department
Physiology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Choi, Charles; Nitabach, Michael N (2013) Membrane-tethered ligands: tools for cell-autonomous pharmacological manipulation of biological circuits. Physiology (Bethesda) 28:164-71
Choi, Charles; Cao, Guan; Tanenhaus, Anne K et al. (2012) Autoreceptor control of peptide/neurotransmitter corelease from PDF neurons determines allocation of circadian activity in drosophila. Cell Rep 2:332-44
Correa, Diego; Segal, Steven S (2012) Neurovascular proximity in the diaphragm muscle of adult mice. Microcirculation 19:306-15
Hesse, Eric; Saito, Hiroaki; Kiviranta, Riku et al. (2010) Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity. J Cell Biol 191:1271-83
Choi, Charles; Fortin, Jean-Philippe; McCarthy, Ellena v et al. (2009) Cellular dissection of circadian peptide signals with genetically encoded membrane-tethered ligands. Curr Biol 19:1167-75
Long, Jennifer B; Segal, Steven S (2009) Quantifying perivascular sympathetic innervation: regional differences in male C57BL/6 mice at 3 and 20 months. J Neurosci Methods 184:124-8
Uhrenholt, Torben R; Domeier, Timothy L; Segal, Steven S (2007) Propagation of calcium waves along endothelium of hamster feed arteries. Am J Physiol Heart Circ Physiol 292:H1634-40
Domeier, Timothy L; Segal, Steven S (2007) Electromechanical and pharmacomechanical signalling pathways for conducted vasodilatation along endothelium of hamster feed arteries. J Physiol 579:175-86
Looft-Wilson, Robin C; Haug, Sara J; Neufer, P Darrell et al. (2004) Independence of connexin expression and vasomotor conduction from sympathetic innervation in hamster feed arteries. Microcirculation 11:397-408
Haug, Sara J; Welsh, Donald G; Segal, Steven S (2003) Sympathetic nerves inhibit conducted vasodilatation along feed arteries during passive stretch of hamster skeletal muscle. J Physiol 552:273-82

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