The University of Michigan (UM) Genetics Training Program (GTP) is one of the first NIH-supported training grants and is in the 40th year of continuous funding. Six basic science departments on the UM medical school and undergraduate campuses comprise the GTP: (1) Biological Chemistry; (2) Ecology and Evolutionary Biology; (3) Human Genetics; (4) Microbiology and Immunology; (5) Molecular, Cellular, and Developmental Biology; and (6) Pharmacology. The GTP is centered on outstanding faculty and trainees, their associated research programs, and the GTP curriculum. The GTP has thrived within the context of the multi-disciplinary graduate Program in Biomedical Sciences, and is a flagship interdisciplinary graduate training program at UM. More than 235 GTP trainees have received Ph.D. degrees; the majority of those trainees have gone on to productive careers in genetics. The primary mission of the GTP is to recruit a diverse population of outstanding Ph.D. and M.D./Ph.D. scholars who conduct thesis research with a strong genetic component, and to enhance their training with a comprehensive, interdisciplinary curriculum in all aspects of modern genetic research. The GTP is designed to ensure that accepted students are rigorously trained in genetics, the scientific disciplines of their home department, and the scientific focus of their thesis research laboratory. To accomplish this goal, GTP trainees enroll in a common core of genetics coursework that is designed to complement the curriculum of their home department. The dissertation projects of trainees must have a foundation in genetics, and further guidance is achieved by including a second GTP faculty member on each thesis dissertation committee. Through courses, seminars, and informal interactions, GTP trainees become familiar with modern genetic research and the strengths and applicability of a variety of genetic model systems. Through recently developed programs, GTP trainees gain competence in using genetic databases as well as quantitative and statistical methods for data analysis. The GTP monitors all trainees to ensure that we graduate well-trained geneticists. The GTP continues to evolve to ensure that trainees are able to address cutting-edge research questions in genetics from multiple perspectives and that they are prepared for a productive career in the current varied and demanding scientific environment. Importantly, the GTP strives to include a diverse body of trainees. During the past funding period, our recruitment of outstanding scholars from underrepresented minority groups increased from 7% to over 21%. The GTP has a body of 69 well-funded, productive faculty mentors at varied career stages with diverse interests in genetics. The GTP Executive Committee ensures that each faculty member is engaged with GTP trainees through seminars, chalk talks, and poster sessions throughout the academic year. In sum, the GTP is a premier training program at UM that provides rigorous graduate training in genetics to trainees on the medical school and main campuses. Notably, UM recognizes these efforts by providing over $1.1 million to support the academic mission of the GTP.

Public Health Relevance

The ever-changing landscape of genetic research requires the training of scientists in state-of-the-art genetics and genomics technologies to answer fundamental, mechanistic biological questions that inform us about human biology and disease. The University of Michigan Pre-doctoral Genetics Training Program combines an outstanding scientific environment, diverse and productive faculty and student trainees, small-group learning experiences, and a comprehensive curriculum in modern genetics that prepares the next generation of scientists for a productive career in the current varied and demanding scientific environment.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007544-43
Application #
9975852
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Bender, Michael T
Project Start
1978-07-01
Project End
2023-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
43
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Genetics
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Moccia, Amanda; Martin, Donna M (2018) Nervous system development and disease: A focus on trithorax related proteins and chromatin remodelers. Mol Cell Neurosci 87:46-54
McCrone, John T; Woods, Robert J; Martin, Emily T et al. (2018) Stochastic processes constrain the within and between host evolution of influenza virus. Elife 7:
Bélanger, Catherine; Bérubé-Simard, Félix-Antoine; Leduc, Elizabeth et al. (2018) Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome. Proc Natl Acad Sci U S A 115:E620-E629
Cheung, Leonard Y M; George, Akima S; McGee, Stacey R et al. (2018) Single-Cell RNA Sequencing Reveals Novel Markers of Male Pituitary Stem Cells and Hormone-Producing Cell Types. Endocrinology 159:3910-3924
Rips, Jonathan; Meyer-Schuman, Rebecca; Breuer, Oded et al. (2018) MARS variant associated with both recessive interstitial lung and liver disease and dominant Charcot-Marie-Tooth disease. Eur J Med Genet 61:616-620
Keil, Jason M; Qalieh, Adel; Kwan, Kenneth Y (2018) Brain transcriptome databases: a user's guide. J Neurosci :
Wang, Yu; Ji, Tuo; Nelson, Andrew D et al. (2018) Critical roles of ?II spectrin in brain development and epileptic encephalopathy. J Clin Invest 128:760-773
McCrone, John T; Lauring, Adam S (2018) Genetic bottlenecks in intraspecies virus transmission. Curr Opin Virol 28:20-25
Law, William D; Fogarty, Elizabeth A; Vester, Aimée et al. (2018) A genome-wide assessment of conserved SNP alleles reveals a panel of regulatory SNPs relevant to the peripheral nerve. BMC Genomics 19:311
Nelson, A D; Caballero-Florán, R N; Rodríguez Díaz, J C et al. (2018) Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. Mol Psychiatry :

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