The world has recently witnessed unprecedented advances in biomedical research and discovery. We have observed technological miracles including isolation of human embryonic stem cells, completion of the human genome project, generation of new heart valves from stem cells and the discovery of novel genetic risk factors through genome-wide screens. With the rapid development and application of new technologies to biomedical research, enormous progress has been made in understanding basic human biology and disease. However, the translation of this knowledge to the discovery, development and optimal use of pharmacological therapies has not kept pace. This slow progress can be attributed, primarily, to two factors: 1) a severe shortage of well trained, qualified clinical pharmacology investigators, nationally, who can fulfill this need for translational research and, 2) a marked contraction of training opportunities within the U.S. At UCSF, we are keenly aware of what has been described as an ?overwhelming mandate? to train the next generation of clinical pharmacologist researchers. We are uniquely positioned to fulfill the growing and evolving needs of adult and pediatric clinical pharmacology through the recruitment of a diverse and highly motivated pool of M.D., Pharm.D. and Ph.D. trainees into our research-intensive Clinical Pharmacology and Therapeutics Postdoctoral Training Program (https://pharm.ucsf.edu/cpt). For the past 54 years, the UCSF Clinical Pharmacology Training program has consistently produced clinical pharmacologists of the highest caliber. In this competing renewal application, we propose to continue and extend our highly successful clinical pharmacology-training program, which includes seven two-year fellowship positions. Our fellows will be educated in translational research ? from basic science to clinical application ? through our mentored research training, didactic coursework and participation in a biweekly seminar series. Faculty mentors in the program, committed to training our fellows, have high impact, NIH-funded research programs and teaching careers. Drs. Burchard and Floren lead the program. Dr. Burchard, M.D., M.P.H., studies genetics and pharmacogenetics in minority children. Dr. Burchard served as an advisor to the Director for the National Institutes of Health's ?All of Us? initiative. Dr. Floren, PharmD., is the Director of Advanced Scientific and Clinical Training for the UCSF PharmD program. Our research strengths include pediatric pharmacology, vulnerable populations, pharmacogenomics, pharmacometrics, systems pharmacology and regulatory sciences. Our program will help create a well-trained and diverse group of clinical-scientist investigators who will serve as tomorrow's leaders in clinical pharmacology research and practice in academia as well as the pharmaceutical, biotechnology industries and regulatory agencies.
The goal of the Clinical Pharmacology and Therapeutics (CPT) Postdoctoral Training Program at UCSF is to train the next generation of clinical pharmacologist researchers so that they may pursue independently funded careers as academic investigators or clinical pharmacologists who can translate advances in biomedical research to the discovery, development and use of pharmacological therapies. We achieve this goal through a rigorous program structure of mentored research training accompanied by didactic coursework and participation in a biweekly seminar series. Throughout the course of the training program, trainees are exposed to a wide variety of research topics and interests leading to the development of a well-trained and diverse group of clinical-scientist investigators who will serve as tomorrow's leaders in clinical pharmacology research and practice in academia as well as the pharmaceutical, biotechnology industries and regulatory agencies.
|Wallender, Erika; Vucicevic, Katarina; Jagannathan, Prasanna et al. (2018) Predicting Optimal Dihydroartemisinin-Piperaquine Regimens to Prevent Malaria During Pregnancy for Human Immunodeficiency Virus-Infected Women Receiving Efavirenz. J Infect Dis 217:964-972|
|Oni-Orisan, Akinyemi; Hoffmann, Thomas J; Ranatunga, Dilrini et al. (2018) Characterization of Statin Low-Density Lipoprotein Cholesterol Dose-Response Using Electronic Health Records in a Large Population-Based Cohort. Circ Genom Precis Med 11:e002043|
|Liakoni, Evangelia; Gugelmann, Hallam; Dempsey, Delia A et al. (2018) Butanediol conversion to gamma-hydroxybutyrate markedly reduced by the alcohol dehydrogenase blocker fomepizole. Clin Pharmacol Ther :|
|Zeiger, Andrew M; White, Marquitta J; Eng, Celeste et al. (2018) Genetic Determinants of Telomere Length in African American Youth. Sci Rep 8:13265|
|Savic, Rada M; Jagannathan, Prasanna; Kajubi, Richard et al. (2018) Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine. Clin Infect Dis 67:1079-1088|
|Jagannathan, Prasanna; Kakuru, Abel; Okiring, Jaffer et al. (2018) Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial. PLoS Med 15:e1002606|
|Park, Danny S; Eskin, Itamar; Kang, Eun Yong et al. (2018) An ancestry-based approach for detecting interactions. Genet Epidemiol 42:49-63|
|Bartelink, I H; Zhang, N; Keizer, R J et al. (2017) New Paradigm for Translational Modeling to Predict Long-term Tuberculosis Treatment Response. Clin Transl Sci 10:366-379|
|Ippolito, Matthew M; Johnson, Julia; Mullin, Christopher et al. (2017) The Relative Effects of Artemether-lumefantrine and Non-artemisinin Antimalarials on Gametocyte Carriage and Transmission of Plasmodium falciparum: A Systematic Review and Meta-analysis. Clin Infect Dis 65:486-494|
|Oh, Sam S; Du, Randal; Zeiger, Andrew M et al. (2017) Breastfeeding associated with higher lung function in African American youths with asthma. J Asthma 54:856-865|
Showing the most recent 10 out of 128 publications