This is a continuing application for a 5-51/2 year Ph.D. (only) program in the Pharmacological Sciences. The first year of training in biomedical sciences at Vanderbilt University Medical Center is Interdisciplinary, and involves participation in a year long bio-regulation core course. Students who select preceptors in the Pharmacological Sciences Training Program in May of their first year then begin the required course work for this graduate program, including: Pharmacological Targets and Mechanisms Systems (including in vivo physiology and drug disposition); Receptors and Signal Transduction; The Pharmacological Basis of Drug Action; and Scientific Communications. In addition, students take at least six additional hours of elective courses to accommodate individual interests and needs. Research opportunities are available in six general areas: Receptor Mechanisms and Signal Transduction, Molecular mechanisms for Cellular Regulation, Neuro-pharmacology, Cardiovascular Pharmacology, Pharmacology of Arachidonic Acid Metabolites, and Drug Disposition and Pharmacokinetics. Course work is complemented by other important didactic experiences: weekly Journal Club; a student-invited annual Pharmacology Forum; an annual Department of Pharmacology Retreat for presenting upcoming research goals; and exchange programs between Vanderbilt and Meharry medical College to strengthen the broad-based education of our students as well as to foster the careers of under-represented minorities in research. Comprehensive qualifying examinations and defense of the dissertation proposal precedes dissertation research; dissertation committee meetings occur frequently, to facilitate mentoring. The breadth of interest of the faculty, their international recognition and success in acquiring extramural peer-reviewed support, their understanding of the scientific process and our emphasis on scientific integrity make our program an outstanding environment for the training of independent scientists in the area of pharmacological sciences. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007628-30
Application #
7259345
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Preusch, Peter C
Project Start
1978-07-01
Project End
2008-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
30
Fiscal Year
2007
Total Cost
$367,779
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pharmacology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Stansley, Branden J; Fisher, Nicole M; Gogliotti, Rocco G et al. (2018) Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5. Cereb Cortex 28:4291-4304
Steiner, Bradley D; Eberly, Allison R; Hurst, Melanie N et al. (2018) Evidence of Cross-Regulation in Two Closely Related Pyruvate-Sensing Systems in Uropathogenic Escherichia coli. J Membr Biol 251:65-74
Fisher, Nicole M; Seto, Mabel; Lindsley, Craig W et al. (2018) Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders. Front Mol Neurosci 11:387
Yim, Yun Young; Zurawski, Zack; Hamm, Heidi (2018) GPCR regulation of secretion. Pharmacol Ther 192:124-140
Kharade, Sujay V; Kurata, Haruto; Bender, Aaron M et al. (2018) Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol 94:926-937
Fisher, Nicole M; Gogliotti, Rocco G; Vermudez, Sheryl Anne D et al. (2018) Genetic Reduction or Negative Modulation of mGlu7 Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome. ACS Chem Neurosci 9:2210-2217
Bolus, W Reid; Peterson, Kristin R; Hubler, Merla J et al. (2018) Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments. Mol Metab 8:86-95
Yuasa, Masato; Saito, Masanori; Molina, Cesar et al. (2018) Unexpected timely fracture union in matrix metalloproteinase 9 deficient mice. PLoS One 13:e0198088
Yang, Zhenlin; Han, Shuo; Keller, Max et al. (2018) Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor. Nature 556:520-524
Duncan, D'Anne S; Weiner, Rebecca L; Weitlauf, Carl et al. (2018) Ccl5 Mediates Proper Wiring of Feedforward and Lateral Inhibition Pathways in the Inner Retina. Front Neurosci 12:702

Showing the most recent 10 out of 178 publications