This is a continuing application for a Ph.D. (only) program in the Pharmacological Sciences. Graduate student trainees from Vanderbilt University or Meharry Medical College may be supported for up to two years of graduate training, generally years 2 and 3 of training. The first year of training in biomedical sciences at Vanderbilt University is Interdisciplinary, and involves participation in an academic year long core curriculum. Students select preceptors in the Pharmacological Sciences Training Program in May at the end of the first year of graduate school before beginning the required course work for this graduate program. Program specific curriculum includes: Receptor Theory Module (short course); Fundamentals of Pharmacology: Receptor Theory & Signal Transduction Pathways; Drug Metabolism & Pharmacokinetics; Scientific Communication Skills I & II; Targets, Systems, and Drug Action; Experimental Design and training in Responsible Conduct of Research. In addition, students take at least six additional hours of elective courses to accommodate individual interests and needs. The curriculum for Meharry trainees is similar and cross registration agreements between Vanderbilt and Meharry results in Meharry trainees completing at least some of the above courses with Vanderbilt trainees. Research opportunities are available in several areas at both institutions: Receptor Mechanisms and Signal Transduction, Molecular mechanisms for Cellular Regulation, Neuropharmacology, Cardiovascular Pharmacology, Cancer Pharmacology, Pharmacology of Anti-Infective Agents, Clinical Pharmacology, Drug Discovery, and Drug Disposition and Pharmacokinetics. Course work is complemented by other important didactic experiences: weekly Journal Club; a student-invited annual Pharmacology Forum; an annual Department of Pharmacology Retreat for presenting upcoming research goals; and exchange programs between Vanderbilt and Meharry Medical College to strengthen the broad-based education of our students as well as to foster the careers of under-represented minorities in research. The training environment is further strengthened by partnerships with the Lipscomb College of Pharmacy, the ability of trainees to participate in a Program in Molecular Medicine, and the presence of a highly successful, in-house Drug Discovery Program. Comprehensive qualifying examinations and defense of the dissertation proposal precedes dissertation research. After admission to candidacy for degree, dissertation committee meetings occur frequently to facilitate mentoring. The breadth of interest of the faculty, their international recognition and success in acquiring extramural peer-reviewed support, their understanding of the scientific process, and an emphasis on scientific integrity make our program an outstanding environment for the training of independent scientists in the area of pharmacological sciences.

Public Health Relevance

Students are funded to provide training in the discipline of Pharmacology; the science of drug development and testing. Training includes coursework and original research in a laboratory. Scientists trained in this area perform important jobs in drug development in universities and industries, product safety, and regulatory affairs.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007628-43
Application #
9948657
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Koduri, Sailaja
Project Start
1978-07-01
Project End
2023-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
43
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pharmacology
Type
Schools of Medicine
DUNS #
965717143
City
Nashville
State
TN
Country
United States
Zip Code
37203
Gogliotti, Rocco G; Fisher, Nicole M; Stansley, Branden J et al. (2018) Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M4 Muscarinic Receptor as a Novel Therapeutic Target. J Pharmacol Exp Ther 365:291-300
Shonesy, Brian C; Parrish, Walker P; Haddad, Hala K et al. (2018) Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior. Biol Psychiatry 84:304-315
Stansley, Branden J; Fisher, Nicole M; Gogliotti, Rocco G et al. (2018) Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5. Cereb Cortex 28:4291-4304
Steiner, Bradley D; Eberly, Allison R; Hurst, Melanie N et al. (2018) Evidence of Cross-Regulation in Two Closely Related Pyruvate-Sensing Systems in Uropathogenic Escherichia coli. J Membr Biol 251:65-74
Fisher, Nicole M; Seto, Mabel; Lindsley, Craig W et al. (2018) Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders. Front Mol Neurosci 11:387
Yim, Yun Young; Zurawski, Zack; Hamm, Heidi (2018) GPCR regulation of secretion. Pharmacol Ther 192:124-140
Kharade, Sujay V; Kurata, Haruto; Bender, Aaron M et al. (2018) Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol 94:926-937
Fisher, Nicole M; Gogliotti, Rocco G; Vermudez, Sheryl Anne D et al. (2018) Genetic Reduction or Negative Modulation of mGlu7 Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome. ACS Chem Neurosci 9:2210-2217
Bolus, W Reid; Peterson, Kristin R; Hubler, Merla J et al. (2018) Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments. Mol Metab 8:86-95
Yuasa, Masato; Saito, Masanori; Molina, Cesar et al. (2018) Unexpected timely fracture union in matrix metalloproteinase 9 deficient mice. PLoS One 13:e0198088

Showing the most recent 10 out of 178 publications