The proposed training program is the centerpiece in efforts to provide postdoctoral training in laboratory genetics for medical geneticists at Harvard Medical School (HMS). This program has made possible the opportunity to offer training to physicians and scientists in a wide variety of disciplines, enabling them to take advantage of the extraordinarily rich academic environment offered at HMS and its affiliated institutions as well as the greater Boston scientific community. In addition, it has served to promote interactions between investigators and provided a forum for increasing faculty contact with trainees in didactic sessions. The training laboratories of the program have historically been centered at HMS and its affiliated institutions including Brigham and Women's Hospital (BWH), the HMS Department of Genetics, Beth Israel Deaconess Medical Center (BIDMC), Children's Hospital Boston (CHB), Dana Farber Cancer Institute (DFCI), and Massachusetts General Hospital (MGH), and more recently have also included laboratories at the Massachusetts Institute of Technology (MIT). Shortly before the last renewal of this training grant, the Harvard Medical School-Partners HealthCare Center for Genetics and Genomics (HPCGG) was initiated. One of the HPCGG's goals is to facilitate training of the next generation of medical geneticists and the HMS Training Grant in Genetics is an integral component in accomplishing this goal. Most recently, the creation of the Broad Institute of MIT and Harvard has even further enhanced training opportunities for geneticists in Boston. The focus of this training is medical and human genetics, and the program is fully integrated with the HMS American Board of Medical Genetics (ABMG) training program, which is accredited by the ABMG in all areas of training (Clinical Genetics, Ph.D. Medical Genetics, Biochemical Genetics, Cytogenetics, and Molecular Genetics), providing the opportunity for trainees to become active candidates for the certification examination in a discipline(s) of medical genetics in addition to receiving laboratory training for two to three years. Since the last renewal of this T32, we have successfully implemented combined residency training programs in Internal Medicine and Medical Genetics and in Pediatrics and Medical Genetics in addition to subspecialty training in Molecular Genetic Pathology.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007748-33
Application #
8101274
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PG))
Program Officer
Haynes, Susan R
Project Start
1979-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
33
Fiscal Year
2011
Total Cost
$346,010
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Guissart, Claire; Latypova, Xenia; Rollier, Paul et al. (2018) Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia. Am J Hum Genet 102:744-759
Takeda, David Y; Spisák, Sándor; Seo, Ji-Heui et al. (2018) A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer. Cell 174:422-432.e13
Rohanizadegan, Mersedeh; Sacharow, Stephanie (2018) Desmosterolosis presenting with multiple congenital anomalies. Eur J Med Genet 61:152-156
Gray, Kathryn J; Saxena, Richa; Karumanchi, S Ananth (2018) Genetic predisposition to preeclampsia is conferred by fetal DNA variants near FLT1, a gene involved in the regulation of angiogenesis. Am J Obstet Gynecol 218:211-218
Pectasides, Eirini; Stachler, Matthew D; Derks, Sarah et al. (2018) Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma. Cancer Discov 8:37-48
Viswanatha, Raghuvir; Li, Zhongchi; Hu, Yanhui et al. (2018) Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells. Elife 7:
Currall, Benjamin B; Chen, Ming; Sallari, Richard C et al. (2018) Loss of LDAH associated with prostate cancer and hearing loss. Hum Mol Genet 27:4194-4203
Arachchi, Harindra; Wojcik, Monica H; Weisburd, Benjamin et al. (2018) matchbox: An open-source tool for patient matching via the Matchmaker Exchange. Hum Mutat 39:1827-1834
Jones, Kelly L; McNamara, Erin A; Longoni, Mauro et al. (2018) Dual diagnoses in 152 patients with Turner syndrome: Knowledge of the second condition may lead to modification of treatment and/or surveillance. Am J Med Genet A 176:2435-2445
Wojcik, Monica H; Schwartz, Talia S; Yamin, Inbar et al. (2018) Genetic disorders and mortality in infancy and early childhood: delayed diagnoses and missed opportunities. Genet Med 20:1396-1404

Showing the most recent 10 out of 113 publications