The goal of the proposed Genetics, Cellular and Molecular Sciences Training Grant (GCMSTG) is to provide comprehensive, relevant and engaging pre-doctoral training in the molecular sciences across a range of scales from atomic resolution, through macromolecules, to the cell and its structure, and to populations of cells and tissues. Fifty six Training Faculties from the Indiana University Biology, Biochemistry and Chemistry departments and the Medical Sciences Program, cover a broad range of expertise and research interests that encompass diverse disciplines including biochemistry, development, cell biology, microbiology, molecular genetics, structural biology, and molecular evolution. Trainees have the opportunity to engage in the highly collaborative and stimulating intellectual environment facilitated by a large, integrated faculty who span a tremendous breadth of life science research. Trainees enroll in a core curriculum designed to teach molecular science from a primary research perspective. Courses on literature analysis, grant writing, teaching and ethics, plus opportunities to develop presentation skills complement the core curriculum. Trainees cultivate their specific interests with advanced coursework. Throughout their studies, students are extensively mentored by the Training Faculty, the TG Committee and their thesis committees. Specific training grant activities including a yearly symposium, a monthly trainee meeting, travel support, and opportunities to meet with visiting seminar speakers, enhance their experience, and create a rich intellectual environment. Many students supported though the GCMSTG are from the Molecular, Biology and Genetics graduate program in the Biology Department, although a significant number of trainees with a molecular biological focus will also be supported from the Ecology, Evolution and Behavior program in Biology, and the Interdisciplinary Biochemistry and Medical Sciences graduate programs. The lU GCMSTG has a long and outstanding track record of training pre-doctoral students, who go on to develop successful and productive careers in academic and industrial life science sectors. This resubmitted proposal requests continuation of 16 training positions, through which we will contribute to and enhance this tradition.

Public Health Relevance

The lU GCMS TG enables talented pre-doctoral students to realize their potential and develop into outstanding life scientists, contributing to human health and society at many different levels. Comprehensive coursework, careful mentoring, advanced facilities, intensive scientific discourse and teaching, creates a program in which dedicated students thrive, and propel their careers forward into the biomedical sciences.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZGM1-BRT-X (TR))
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Haynes, Susan R
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Indiana University Bloomington
Schools of Arts and Sciences
United States
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Foster, Patricia L; Niccum, Brittany A; Popodi, Ellen et al. (2018) Determinants of Base-Pair Substitution Patterns Revealed by Whole-Genome Sequencing of DNA Mismatch Repair Defective Escherichia coli. Genetics 209:1029-1042
Whitaker, Briana K; Reynolds, Heather L; Clay, Keith (2018) Foliar fungal endophyte communities are structured by environment but not host ecotype in Panicum virgatum (switchgrass). Ecology 99:2703-2711
McKinlay, Anastasia; Podicheti, Ram; Wendte, Jered M et al. (2018) RNA polymerases IV and V influence the 3' boundaries of Polymerase II transcription units in Arabidopsis. RNA Biol 15:269-279
Niccum, Brittany A; Lee, Heewook; MohammedIsmail, Wazim et al. (2018) The Spectrum of Replication Errors in the Absence of Error Correction Assayed Across the Whole Genome of Escherichia coli. Genetics 209:1043-1054
Zee, Peter C; Velicer, Gregory J (2017) Parallel emergence of negative epistasis across experimental lineages. Evolution 71:1088-1095
Wendte, Jered M; Haag, Jeremy R; Singh, Jasleen et al. (2017) Functional Dissection of the Pol V Largest Subunit CTD in RNA-Directed DNA Methylation. Cell Rep 19:2796-2808
Adrion, Jeffrey R; Song, Michael J; Schrider, Daniel R et al. (2017) Genome-Wide Estimates of Transposable Element Insertion and Deletion Rates in Drosophila Melanogaster. Genome Biol Evol 9:1329-1340
Wendte, Jered M; Pikaard, Craig S (2017) The RNAs of RNA-directed DNA methylation. Biochim Biophys Acta Gene Regul Mech 1860:140-148
Ramsey, Jolene; Renzi, Emily C; Arnold, Randy J et al. (2017) Palmitoylation of Sindbis Virus TF Protein Regulates Its Plasma Membrane Localization and Subsequent Incorporation into Virions. J Virol 91:
Feirer, Nathan; Kim, DohHyun; Xu, Jing et al. (2017) The Agrobacterium tumefaciens CheY-like protein ClaR regulates biofilm formation. Microbiology :

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