Continued support is requested for an ongoing program of graduate research training in molecular biology and biophysics at the University of Oregon. This training activity is centered in the Institute of Molecular Biology, and also involves additional groups with related scientific interests. Funds are requested for 12 predoctoral positions, within a program that includes approximately 59 graduate students, 47 postdoctoral trainees, and 22 training faculty. The program places special emphasis on the control of gene expression and nucleic acid structure/function, molecular basis of signaling and cell function, protein structure and dynamics, and molecular approaches to development and differentiation. The basic aspect of the training is laboratory research carried out under the direction of a facult member in the molecular biology and biophysics training program. Through this experience, the trainee becomes skilled at posing questions about fundamental biological processes and designing experiments to answer those questions. The training is augmented by formal courses offered by the Biology, Chemistry, and Physics Departments, by seminar programs that highlight current research in molecular biology, biophysics, and related disciplines, by the close involvement of a Thesis Advisory Committee, and by research seminar and journal club presentations by trainees. The training facilities include the laboratories of the faculty and support services such as the structural biology biophysical facility, the state-of-the-art genomics and imaging facilities, and a large number of other modern facilities. Major equipment is shared and housed in common space. The laboratories of most of the faculty are contiguous and in interconnected buildings. This arrangement fosters strong interdisciplinary interactions and collaborations among faculty and students.

Public Health Relevance

This proposal is to provide support for graduate training leading to the Ph.D. degree in molecular biology and biophysics. Our goal is to produce creative, intellectually critical, and experimentally skilled bioscientists. We believe that trainig towards this end is first and foremost accomplished at the laboratory bench, and training is focused on learning to find a rigorous experimental answer to a significant scientific question. The training program actively promotes strongly interdisciplinary and collaborative science. We want our students to develop into imaginative and capable research scientists, equipped with the knowledge to lead research programs of their own, thereby strengthening the national resource in this area.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-BRT-X (TR))
Program Officer
Flicker, Paula F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Oregon
Organized Research Units
United States
Zip Code
Luan, Qing; Liu, Su-Ling; Helgeson, Luke A et al. (2018) Structure of the nucleation-promoting factor SPIN90 bound to the actin filament nucleator Arp2/3 complex. EMBO J 37:
Duvvuri, Hiranmayi; Wheeler, Lucas C; Harms, Michael J (2018) pytc: Open-Source Python Software for Global Analyses of Isothermal Titration Calorimetry Data. Biochemistry 57:2578-2583
Schlomann, Brandon H; Wiles, Travis J; Wall, Elena S et al. (2018) Bacterial Cohesion Predicts Spatial Distribution in the Larval Zebrafish Intestine. Biophys J 115:2271-2277
Piñas, Germán E; DeSantis, Michael D; Parkinson, John S (2018) Noncritical Signaling Role of a Kinase-Receptor Interaction Surface in the Escherichia coli Chemosensory Core Complex. J Mol Biol 430:1051-1064
Wiles, Travis J; Wall, Elena S; Schlomann, Brandon H et al. (2018) Modernized Tools for Streamlined Genetic Manipulation and Comparative Study of Wild and Diverse Proteobacterial Lineages. MBio 9:
Wheeler, Lucas C; Anderson, Jeremy A; Morrison, Anneliese J et al. (2018) Conservation of Specificity in Two Low-Specificity Proteins. Biochemistry 57:684-695
Balzer, Connor J; Wagner, Andrew R; Helgeson, Luke A et al. (2018) Dip1 Co-opts Features of Branching Nucleation to Create Linear Actin Filaments that Activate WASP-Bound Arp2/3 Complex. Curr Biol 28:3886-3891.e4
Fierro Jr, Javier; Haynes, Dylan R; Washbourne, Philip (2018) 4.1Ba is necessary for glutamatergic synapse formation in the sensorimotor circuit of developing zebrafish. PLoS One 13:e0205255
Schlomann, Brandon H (2018) Stationary moments, diffusion limits, and extinction times for logistic growth with random catastrophes. J Theor Biol 454:154-163
Miranda, Rafael G; McDermott, James J; Barkan, Alice (2018) RNA-binding specificity landscapes of designer pentatricopeptide repeat proteins elucidate principles of PPR-RNA interactions. Nucleic Acids Res 46:2613-2623

Showing the most recent 10 out of 126 publications