Abstract

The goal of this training program is to produce students with a broad multi-disciplinary background that enables them to use a variety of approaches to solve important problems in the field of neurobiology. To this end, students complete courses that span neurobiology from the neuroanatomical, neurophysiological, and developmental to the cellular, molecular and behavioral. Formal course work is augmented by weekly seminars, journal clubs, and ah annual retreat. A group of 48 trainers provide excellent opportunities for students to pursue their diverse research interests with experienced and skilled mentors. Since our last submission, the number of applicants to-Neurobiology has doubled an increase that has not been reflected in the number of training grant slots. We are therefore requesting that the number of positions on this training grant be increased to 12, to keep up with our recent and projected growth.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007839-31
Application #
7883170
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Hagan, Ann A
Project Start
1985-07-01
Project End
2013-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
31
Fiscal Year
2010
Total Cost
$306,141
Indirect Cost

  Institution

Name
University of Chicago
Department
Biology
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Andrew, Robert J; Fernandez, Celia G; Stanley, Molly et al. (2017) Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A 114:E9665-E9674
Pusic, Aya D; Mitchell, Heidi M; Kunkler, Phillip E et al. (2015) Spreading depression transiently disrupts myelin via interferon-gamma signaling. Exp Neurol 264:43-54
Opal, M D; Klenotich, S C; Morais, M et al. (2014) Serotonin 2C receptor antagonists induce fast-onset antidepressant effects. Mol Psychiatry 19:1106-14
Gururangan, Suchin S; Sadovsky, Alexander J; MacLean, Jason N (2014) Analysis of graph invariants in functional neocortical circuitry reveals generalized features common to three areas of sensory cortex. PLoS Comput Biol 10:e1003710
Pusic, Aya D; Kraig, Richard P (2014) Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination. Glia 62:284-99
Sadovsky, Alexander J; MacLean, Jason N (2014) Mouse visual neocortex supports multiple stereotyped patterns of microcircuit activity. J Neurosci 34:7769-77
Runfeldt, Melissa J; Sadovsky, Alexander J; MacLean, Jason N (2014) Acetylcholine functionally reorganizes neocortical microcircuits. J Neurophysiol 112:1205-16
Buggia-Prévot, Virginie; Fernandez, Celia G; Riordan, Sean et al. (2014) Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase. Mol Neurodegener 9:1
Priest, Michael F; Lacroix, Jérôme J; Villalba-Galea, Carlos A et al. (2013) S3-S4 linker length modulates the relaxed state of a voltage-gated potassium channel. Biophys J 105:2312-22
Sadovsky, Alexander J; MacLean, Jason N (2013) Scaling of topologically similar functional modules defines mouse primary auditory and somatosensory microcircuitry. J Neurosci 33:14048-60, 14060a

Showing the most recent 10 out of 58 publications