The Pittsburgh MSTP brings together the synergetic research and clinical strengths of Carnegie Mellon University of the University of Pittsburgh. Trainees are selected from a national pool of over 400 applicants with superior academic records. Our program prepares trainees for careers as physician scientists through rigorous research training, a MSTP-specific curriculum comprised of 10 courses or rotations including tiered professional development courses, journal clubs, exposure to interdisciplinary research and ethical training, and events and activities designed to enhance program identify and exposure to role models. The opportunities to participate in top-tier research is broad, with 20 affiliated graduate programs and 118 participating faculty. The curriculum integrates PhD and MD training throughout the course of the program. A subset of students graduate in December and participate in a 5 month MSTP- supported postdoctoral fellowship prior to residency. A core feature of the program is proactive mentoring by Career Advisors individually matched with students at the outset of matriculation. Our IDP process is robust and focuses on development of new skills, identifying resources, framing goals and strategizing to overcome obstacles. Student performance is followed through a comprehensive web-based database with tiered access and yearly Promotions Committee review. Student involvement is integrated into the administrative structure with extensive logistical support and feedback from student committees. Programmatic oversight includes a student-faculty curriculum committee, a Steering committee a Strategic Planning Committee and an External Advisory Board. Average time to completion is 7.7 years. Training outcomes are very strong, with graduates averaging over 5 publications each, with matches to premier residencies and success in academic careers. Currently there are 71 students in the program. Funds are requested to support from 24-28 trainees annually for a period of five years beginning July 2017. Data are provided to support our belief that we have a proven history of attracting outstanding trainees and placing them in positions for future career development.

Public Health Relevance

This application seeks funding to support the training of future physician scientists through a combined MD and PhD program. Our highly integrated, innovative and expedient training program is designed to provide instruction, oversight and mentoring in the basic and clinical sciences, equipping our trainees with a thorough understanding of experimental design and professional skills to succeed at the forefront of biomedical and translational research.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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NIGMS Initial Review Group (TWD)
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Maas, Stefan
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University of Pittsburgh
Internal Medicine/Medicine
Schools of Medicine
United States
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Hoftman, Gil D; Dienel, Samuel J; Bazmi, Holly H et al. (2018) Altered Gradients of Glutamate and Gamma-Aminobutyric Acid Transcripts in the Cortical Visuospatial Working Memory Network in Schizophrenia. Biol Psychiatry 83:670-679
Layden, Alexander J; Täse, Kristos; Finkelstein, Julia L (2018) Neglected tropical diseases and vitamin B12: a review of the current evidence. Trans R Soc Trop Med Hyg 112:423-435
Crum, Raphael; Darren de, S A; Ayeni, Olufemi R et al. (2018) No Difference between Extraction Drilling and Serial Dilation for Tibial Tunnel Preparation in Anterior Cruciate Ligament Reconstruction: A Systematic Review. J ISAKOS 3:
Dienel, Samuel J; Lewis, David A (2018) Alterations in cortical interneurons and cognitive function in schizophrenia. Neurobiol Dis :
Collins, Elliot; Robinson, Amanda K; Behrmann, Marlene (2018) Distinct neural processes for the perception of familiar versus unfamiliar faces along the visual hierarchy revealed by EEG. Neuroimage 181:120-131
Pradhan-Sundd, Tirthadipa; Zhou, Lili; Vats, Ravi et al. (2018) Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology 67:2320-2337
Collins, Elliot; Dundas, Eva; Gabay, Yafit et al. (2017) Hemispheric Organization in Disorders of Development. Vis cogn 25:416-429
Dienel, Samuel J; Bazmi, Holly H; Lewis, David A (2017) Development of transcripts regulating dendritic spines in layer 3 pyramidal cells of the monkey prefrontal cortex: Implications for the pathogenesis of schizophrenia. Neurobiol Dis 105:132-141
Dandachi, Nadine; Kelly, Neil J; Wood, John P et al. (2017) Macrophage Elastase Induces TRAIL-mediated Tumor Cell Death through Its Carboxy-Terminal Domain. Am J Respir Crit Care Med 196:353-363
Harvey, Lloyd D; Chan, Stephen Y (2017) Emerging Metabolic Therapies in Pulmonary Arterial Hypertension. J Clin Med 6:

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