The Integrated Program in Cellular, Molecular and Biomedical Studies (CMBS) at Columbia University Medical Center is a Ph.D. granting interdisciplinary program that combines faculty from all the basic science departments. The CMBS Program is an umbrella program that presents students with a unique opportunity to obtain individualized training in basic cell and molecular biology, microbiology, structural biology, biophysics, genetics, immunology, neurobiology, structural biology, systems biology and computational biology, as well as translational biomedical disease-related research, such as cancer biology and neurodegenerative disease research. Our hope is to train the next leaders in biomedical research and also to provide training for future leaders in other areas where a biomedical research background will be of great benefit. The CMBS program is an accredited degree granting program that was first established in 1986 and has been supported by this Training Grant since 1987. The program has a distinguished, well-funded faculty, whose research expertise represents nearly all the areas of modern cellular and molecular biology, neurobiology and computational biology. Our graduates have gone on to postdoctoral positions in outstanding laboratories, careers in academia, the pharmaceutical or biotechnology industry, or careers where they use their biomedical training to provide other societal benefits. Students take core courses in molecular and cell biology as well as statistics during their first year and complete three laboratory rotations. In the second year, students take their qualifying examination and courses in the Responsible Conduct of Research (lecture and small group discussions). The CMBS Program hosts a student research seminar series and a biennial student faculty retreat. Most students graduate in 5-6 years. The CMBS Program remains the premier cellular and molecular biology graduate program at Columbia University Medical Center and support from this Training Grant is crucial for the continued success of this program.
The goal of this program is to provide doctoral students with a unique opportunity to obtain individualized training in basic cell and molecular biology, microbiology, structural biology, biophysics, genetics, immunology, neurobiology, systems and computational biology, as well as translational biomedical disease-related research.
Van Alstyne, Meaghan; Simon, Christian M; Sardi, S Pablo et al. (2018) Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy. Genes Dev 32:1045-1059 |
Zhang, Liyang; Martini, Gabriella D; Rube, H Tomas et al. (2018) SelexGLM differentiates androgen and glucocorticoid receptor DNA-binding preference over an extended binding site. Genome Res 28:111-121 |
Singh, Appu K; McGoldrick, Luke L; Twomey, Edward C et al. (2018) Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6. Sci Adv 4:eaau6088 |
Singer, Ruth A; Sussel, Lori (2018) Islet Long Noncoding RNAs: A Playbook for Discovery and Characterization. Diabetes 67:1461-1470 |
Weyn-Vanhentenryck, Sebastien M; Feng, Huijuan; Ustianenko, Dmytro et al. (2018) Precise temporal regulation of alternative splicing during neural development. Nat Commun 9:2189 |
Jacko, Martin; Weyn-Vanhentenryck, Sebastien M; Smerdon, John W et al. (2018) Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly. Neuron 97:853-868.e6 |
Yuan, Jinzhou; Levitin, Hanna Mendes; Frattini, Veronique et al. (2018) Single-cell transcriptome analysis of lineage diversity in high-grade glioma. Genome Med 10:57 |
Tzoneva, Gannie; Dieck, Chelsea L; Oshima, Koichi et al. (2018) Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia. Nature 553:511-514 |
Rastogi, Chaitanya; Rube, H Tomas; Kribelbauer, Judith F et al. (2018) Accurate and sensitive quantification of protein-DNA binding affinity. Proc Natl Acad Sci U S A 115:E3692-E3701 |
Twomey, Edward C; Sobolevsky, Alexander I (2018) Structural Mechanisms of Gating in Ionotropic Glutamate Receptors. Biochemistry 57:267-276 |
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