This proposal is for the continuation of the UCLA Intercampus Medical Genetics Post-Doctoral Training Program which utilizes the faculty and facilities of three of the UCLA medical campuses: Cedars-Sinai Medical Center;UCLA Center for the Health Sciences, and Harbor/UCLA Medical Center. This past year we entered into an affiliation agreement with Children's Hospital of Orange County's Biochemical Genetics division. The faculty of this program provides research opportunities varying from basic molecular biology, genomics, cell biology, stem cell research, biochemical genetics, cytogenetics, population genetics, to clinical genetics and dysmorphology. The program has been structured to provide the trainees with Board eligibility by the American Board of Medical Genetics (ABMG), and the Residency Review Committee (RRC) of the Accreditation Council for Graduate Medical Education (ACGME) if they so desire. The primary focus of this NIH funded program is research training in medical genetics of post-doctoral M.D., Ph.D., and D.D.S. candidates who are highly motivated toward academic research careers in the field of medical genetics. The basic aim of the training program is to train individuals with a broad knowledge in medical genetics and an intensive experience in genetic research so they may enter the academic community as independent investigators. They are given a broad experience in medical genetics and intensive research training in molecular, biochemical, population and/or medical genetics for two years under this grant, and additional years for more advanced training are available for qualified trainees. )

Public Health Relevance

All human diseases result from the interaction of genetic variations and environmental factors. Recent advances in genetics are allowing us to identify the genetic variations that contribute to common as well as rare diseases. There is a rapidly increasing need for expertise in genetics at the clinical, biochemical, cellular, molecular and informatics levels. This training program will attract and train bright young scientists and physicians who will then be able to do meaningful research into the causes, prevention and treatment of genetic diseases, as well as perform and interpret the rapidly evolving clinical and genomic tests necessary to accomplish these goals.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008243-27
Application #
8496793
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Haynes, Susan R
Project Start
1987-07-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
27
Fiscal Year
2013
Total Cost
$278,124
Indirect Cost
$19,802
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048
Le, Steven Q; Kan, Shih-Hsin; Clarke, Don et al. (2018) A Humoral Immune Response Alters the Distribution of Enzyme Replacement Therapy in Murine Mucopolysaccharidosis Type I. Mol Ther Methods Clin Dev 8:42-51
Clarke, Don; Pearse, Yewande; Kan, Shih-Hsin et al. (2018) Genetically Corrected iPSC-Derived Neural Stem Cell Grafts Deliver Enzyme Replacement to Affect CNS Disease in Sanfilippo B Mice. Mol Ther Methods Clin Dev 10:113-127
Angarita, Stephanie A K; Truong, Brian; Khoja, Suhail et al. (2018) Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice. Mol Genet Metab 124:114-123
Gallant, N M; Leydiker, K; Wilnai, Y et al. (2017) Biochemical characteristics of newborns with carnitine transporter defect identified by newborn screening in California. Mol Genet Metab 122:76-84
Kan, Shih-Hsin; Le, Steven Q; Bui, Quang D et al. (2016) Behavioral deficits and cholinergic pathway abnormalities in male Sanfilippo B mice. Behav Brain Res 312:265-71
Wang, Jessica Jen-Chu; Rau, Christoph; Avetisyan, Rozeta et al. (2016) Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. PLoS Genet 12:e1006038
Lee, Patrick C; Truong, Brian; Vega-Crespo, Agustin et al. (2016) Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells. Mol Ther Nucleic Acids 5:e394
Marques, Felipe; Tenney, Jessica; Duran, Ivan et al. (2016) Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis. PLoS Genet 12:e1006307
Tai, Denise S; Hu, Chuhong; Kim, Elizabeth H et al. (2015) Augmentation of transgene-encoded protein after neonatal injection of adeno-associated virus improves hepatic copy number without immune responses. Pediatr Res 78:239-246
Rickabaugh, Tammy M; Baxter, Ruth M; Sehl, Mary et al. (2015) Acceleration of age-associated methylation patterns in HIV-1-infected adults. PLoS One 10:e0119201

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