Thermal injury remains a major medical problem throughout the world. Basic researchers are active in burn research, however, trained clinicians are needed to bridge basic science and its clinical application. This renewal application proposes a training program designed to attract and train basic scientist and clinicians in a two year fellowship program dedicated to research on the pathophysiology of burns. The goals of this training program are to mentor talented young doctors in the areas of basic research and clinical investigation, to help them design and perform successful research projects, and teach them scientific ethics and methods of scientific research. Trainees will be selected from a broad group of candidates with special efforts made to identify minority applications. Trainees work and study with a multidisciplinary group of faculty members, most of who have been working together for over 10 years. The major features of the program are didactic training and hands-on research. The basic core consists primarily of course work, seminars, lectures, trainee presentations, and laboratory experience. For the research work, a trainee is directly responsible for a primary project which he or she may propose or may be assigned and also participates in research projects of other trainees and investigators. All projects proceed under the close tutelage of a mentor, and with collaboration of other program faculty members. Candidates require either a MD or a PhD and at least two years of postdoctoral training. Research and training take place at the Shriners Burns Hospital (SBH) and the University of Texas Medical Branch (UTMB). SBH facilities include 40 laboratories specifically designed for research in wound healing, tissue culture, metabolism, microbiology, electron microscopy, large and small animal models, gene analysis, and stable and radioactive isotope analysis. Other UTMB facilities pertinent to the program include the Protein Chemistry Lab, the Ovine Intensive Care Unit and the Clinical Research Center. The postdoctoral fellows' contributions from both animal and human studies have led to the current use of new drugs and therapies to improve morbidity, long term outcomes and in integrating severely burned children back into society. ? ?
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| Culnan, Derek M; Farner, Kelley; Bitz, Genevieve H et al. (2018) Volume Resuscitation in Patients With High-Voltage Electrical Injuries. Ann Plast Surg 80:S113-S118 |
| Bohanon, Fredrick J; Nunez Lopez, Omar; Herndon, David N et al. (2018) Burn Trauma Acutely Increases the Respiratory Capacity and Function of Liver Mitochondria. Shock 49:466-473 |
| Bohanon, Fredrick J; Nunez Lopez, Omar; Adhikari, Deepak et al. (2018) Race, Income and Insurance Status Affect Neonatal Sepsis Mortality and Healthcare Resource Utilization. Pediatr Infect Dis J 37:e178-e184 |
| Cambiaso-Daniel, Janos; Boukovalas, Stafanos; Bitz, Genevieve H et al. (2018) Topical Antimicrobials in Burn Care: Part 1-Topical Antiseptics. Ann Plast Surg : |
| Voigt, Charles D; Hundeshagen, Gabriel; Malagaris, Ioannis et al. (2018) Effects of a restrictive blood transfusion protocol on acute pediatric burn care: Transfusion threshold in pediatric burns. J Trauma Acute Care Surg 85:1048-1054 |
| Cambiaso-Daniel, Janos; Parry, Ingrid; Rivas, Eric et al. (2018) Strength and Cardiorespiratory Exercise Rehabilitation for Severely Burned Patients During Intensive Care Units: A Survey of Practice. J Burn Care Res 39:897-901 |
| Chao, Tony; Porter, Craig; Herndon, David N et al. (2018) Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children. Med Sci Sports Exerc 50:427-435 |
| Murton, Andrew; Bohanon, Fredrick J; Ogunbileje, John O et al. (2018) Sepsis Increases Muscle Proteolysis in Severely Burned Adults, But Does Not Impact Whole-Body Lipid or Carbohydrate Kinetics. Shock : |
| Malagaris, Ioannis; Herndon, David N; Polychronopoulou, Efstathia et al. (2018) Determinants of skeletal muscle protein turnover following severe burn trauma in children. Clin Nutr : |
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