Abstract

The objective of this application is the training of 13 pre-doctoral students per year over the next five years in the interdisciplinary area of molecular biophysics. Trainees will be selected competitively from a pool of approximately 75 graduate students in eight departments of the University of Washington (Biochemistry, Bioengineering, Biological Structure, Chemistry, Immunology, Medicinal Chemistry, Physiology and Biophysics, and Physics) and the Fred Hutchinson Cancer Research Center. The trainees will be exposed to modern molecular biophysics through a series of interdisciplinary courses and seminars and through specialized thesis research. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008268-17
Application #
6764043
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
1988-09-30
Project End
2008-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
17
Fiscal Year
2004
Total Cost
$344,264
Indirect Cost

  Institution

Name
University of Washington
Department
Biochemistry
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Rusnac, Domni?a-Valeria; Lin, Hsiu-Chuan; Canzani, Daniele et al. (2018) Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase. Mol Cell 72:813-822.e4
Dingens, Adam S; Acharya, Priyamvada; Haddox, Hugh K et al. (2018) Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV. PLoS Pathog 14:e1007159
Cornell, Caitlin E; Skinkle, Allison D; He, Shushan et al. (2018) Tuning Length Scales of Small Domains in Cell-Derived Membranes and Synthetic Model Membranes. Biophys J 115:690-701
Borst, Andrew J; Weidle, Connor E; Gray, Matthew D et al. (2018) Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core. Elife 7:
Leonen, Calvin Jon Antolin; Upadhyay, Esha; Chatterjee, Champak (2018) Studies of biochemical crosstalk in chromatin with semisynthetic histones. Curr Opin Chem Biol 45:27-34
Hsu, Peter L; Li, Heng; Lau, Ho-Tak et al. (2018) Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module. Cell 174:1106-1116.e9
Baughman, Hannah E R; Clouser, Amanda F; Klevit, Rachel E et al. (2018) HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation. J Biol Chem 293:2687-2700
Snijder, Joost; Borst, Andrew J; Dosey, Annie et al. (2017) Vitrification after multiple rounds of sample application and blotting improves particle density on cryo-electron microscopy grids. J Struct Biol 198:38-42
Xiong, Xiaoli; Tortorici, M Alejandra; Snijder, Joost et al. (2017) Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections. J Virol :
Borst, Andrew J; James, Zachary M; Zagotta, William N et al. (2017) The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human ?V?3 Integrin via Steric Hindrance. Structure 25:1732-1739.e5

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