Abstract

Continuation of an ongoing interdisciplinary graduate training program in molecular biophysics at the University of Washington is sought. Support for the training of 12 predoctoral students per year is requested. Trainees will be selected competitively from a pool of approximately 100 students who enter the university through ten departments or programs (Biochemistry, Bioengineering, Biomolecular Structure &Design, Chemistry, Medicinal Chemistry, Molecular &Cellular Biology, Medical Scientist Training Program, Microbiology, Pharmacology, and Physiology &Biophysics). Trainee research will be conducted in twenty-nine faculty laboratories housed on the UW campus and at Fred Hutchison Cancer Research Center. Trainees will be exposed to modern molecular biophysics through interdisciplinary course, seminars, and specialized thesis research. Cross-disciplinary training is encouraged through dual mentorship and collaborative research projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008268-23
Application #
8111083
Study Section
Special Emphasis Panel (ZGM1-BRT-X (TG))
Program Officer
Flicker, Paula F
Project Start
1988-09-30
Project End
2014-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
23
Fiscal Year
2011
Total Cost
$314,352
Indirect Cost

  Institution

Name
University of Washington
Department
Biochemistry
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Rusnac, Domni?a-Valeria; Lin, Hsiu-Chuan; Canzani, Daniele et al. (2018) Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase. Mol Cell 72:813-822.e4
Dingens, Adam S; Acharya, Priyamvada; Haddox, Hugh K et al. (2018) Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV. PLoS Pathog 14:e1007159
Cornell, Caitlin E; Skinkle, Allison D; He, Shushan et al. (2018) Tuning Length Scales of Small Domains in Cell-Derived Membranes and Synthetic Model Membranes. Biophys J 115:690-701
Borst, Andrew J; Weidle, Connor E; Gray, Matthew D et al. (2018) Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core. Elife 7:
Leonen, Calvin Jon Antolin; Upadhyay, Esha; Chatterjee, Champak (2018) Studies of biochemical crosstalk in chromatin with semisynthetic histones. Curr Opin Chem Biol 45:27-34
Hsu, Peter L; Li, Heng; Lau, Ho-Tak et al. (2018) Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module. Cell 174:1106-1116.e9
Baughman, Hannah E R; Clouser, Amanda F; Klevit, Rachel E et al. (2018) HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation. J Biol Chem 293:2687-2700
Walls, Alexandra C; Tortorici, M Alejandra; Snijder, Joost et al. (2017) Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion. Proc Natl Acad Sci U S A 114:11157-11162
Laszlo, Kenneth J; Bush, Matthew F (2017) Interpreting the Collision Cross Sections of Native-like Protein Ions: Insights from Cation-to-Anion Proton-Transfer Reactions. Anal Chem 89:7607-7614
Clouser, Amanda F; Klevit, Rachel E (2017) pH-dependent structural modulation is conserved in the human small heat shock protein HSBP1. Cell Stress Chaperones 22:569-575

Showing the most recent 10 out of 165 publications