This proposal requests continued funding of the predoctoral Molecular Biophysics Training Program at the University of Washington (UW). Trainees are chosen through a rigorous selection process that identifies the top graduate students from a large pool of talented applicants admitted to UW through three interdisciplinary programs and nine departmental programs. The major goal of this program is to train students in molecular biophysics, the use of physical and quantitative approaches in the study of biomedically relevant systems, during their graduate career by exposing them to the wide range of research in this area. Students in the Training Program receive training beyond the standard graduate program through a bi-weekly student research presentation series, a student journal club/discussion group, an annual retreat that includes the trainees and their advisors, and through lectures supported by this program. This program plays an important role in training the next generation of scientists for academia, government, and the private sector. The training program has a strong record of success and impact as evidenced by the productivity of its trainees during and after graduate school and by the diverse career choices they make after they leave graduate school.

Public Health Relevance

The Molecular Biophysics Training Program at UW is designed to train the top graduate students at the University of Washington in modern biophysics, the development and application of state-of-the-art physical and quantitative approaches to systems of biomedical importance. The training program plays a special role because it brings together highly talented graduate students from a wide variety of disciplines, such as Biochemistry, Chemistry, Physics, Computer Sciences, and Engineering. This interdisciplinary training experience affords future leaders of academia and industry to broaden their scientific horizons well beyond what they would normally learn in graduate school. The regular programmatic meetings and seminars allow for an important exchange of ideas across disciplines, allowing the trainees to place their studies in a broader context and to consider new applications and approaches to their research.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM008268-26
Application #
8550232
Study Section
(TWD)
Program Officer
Flicker, Paula F
Project Start
1988-09-30
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
26
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Washington
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98195
Rusnac, Domni?a-Valeria; Lin, Hsiu-Chuan; Canzani, Daniele et al. (2018) Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase. Mol Cell 72:813-822.e4
Dingens, Adam S; Acharya, Priyamvada; Haddox, Hugh K et al. (2018) Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV. PLoS Pathog 14:e1007159
Cornell, Caitlin E; Skinkle, Allison D; He, Shushan et al. (2018) Tuning Length Scales of Small Domains in Cell-Derived Membranes and Synthetic Model Membranes. Biophys J 115:690-701
Borst, Andrew J; Weidle, Connor E; Gray, Matthew D et al. (2018) Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core. Elife 7:
Leonen, Calvin Jon Antolin; Upadhyay, Esha; Chatterjee, Champak (2018) Studies of biochemical crosstalk in chromatin with semisynthetic histones. Curr Opin Chem Biol 45:27-34
Hsu, Peter L; Li, Heng; Lau, Ho-Tak et al. (2018) Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module. Cell 174:1106-1116.e9
Baughman, Hannah E R; Clouser, Amanda F; Klevit, Rachel E et al. (2018) HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation. J Biol Chem 293:2687-2700
Walls, Alexandra C; Tortorici, M Alejandra; Snijder, Joost et al. (2017) Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion. Proc Natl Acad Sci U S A 114:11157-11162
Laszlo, Kenneth J; Bush, Matthew F (2017) Interpreting the Collision Cross Sections of Native-like Protein Ions: Insights from Cation-to-Anion Proton-Transfer Reactions. Anal Chem 89:7607-7614
Clouser, Amanda F; Klevit, Rachel E (2017) pH-dependent structural modulation is conserved in the human small heat shock protein HSBP1. Cell Stress Chaperones 22:569-575

Showing the most recent 10 out of 165 publications