Continuation of support is requested for three (3) graduate trainee fellowships in the Molecular Biophysics Program at Wesleyan University. Molecular Biophysics at Wesleyan is an interdisciplinary, interdepartmental program in the Graduate Division of the University in which students pursue doctoral studies via graduate courses, a weekly journal club, an annual retreat, workshops, group meetings, seminars, dissertation research and teaching apprenticeships. The emphasizes collaborative projects among faculty research groups where feasible and interactions between experimentalists and theoreticians. Scientific ethics and the historical and intellectual foundations science figure significantly in the curriculum. The current and proposed program involves faculty of the Departments of Chemistry, Molecular Biology and Biochemistry (MBB), and Physics, with consultation and potential future participation of the Biology department. The participating faculty from Chemistry are Anne M. Baranger (Biological and BiD-organic Chemistry; RNA Folding and RNA-Protein Complex Formation), David L. Beveridge (Theoretical and Computational Bio-physics), Philip H. Bolton (NMR Spectroscopy; Proteins and Nucleic Acids), Rex F. Pratt (Chemistry of Enzymes; Enzymes in Synthesis), and [rina Russu (NMR Spectroscopy, DNA dynamics and Protein-DNA Interactions). The participating faculty from MBB are Ishita Mukerji (UV Resonance Raman Spectroscopy; Protein-DNA Interactions; Protein-Protein Interactions) and Manju Hingorani (Rate Processes and Enzymology of DNA Enzymes). The participating faculty member from the Physics Department is Roderick V. Jensen (Non-linear Dynamics, Computational Neuroscience, Bio-informatics). Participating faculty all have significant independent support for their research programs from extramural funding sources or proposals pending. Wesleyan University is a small, highly selective university emphasizing the liberal arts and sciences at the undergraduate level with Ph.D. programs in the sciences. An undergraduate concentration in Molecular Biophysics has been developed as a complement to our graduate program. Curricular and pedagogical initiatives in this third renewal period will produce a new version of a core course, Introduction to Molecular Biophysics and new courses in Chemical Biology, Advanced Biochemistry, and Kinetic mechanisms and Structural Biology of DNA metabolic enzymes. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008271-19
Application #
7089865
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
1988-09-30
Project End
2008-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
19
Fiscal Year
2006
Total Cost
$106,070
Indirect Cost
Name
Wesleyan University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
145683954
City
Middletown
State
CT
Country
United States
Zip Code
06459
De, Swastik; Kaus, Katherine; Sinclair, Shada et al. (2018) Structural basis of mammalian glycan targeting by Vibrio cholerae cytolysin and biofilm proteins. PLoS Pathog 14:e1006841
Cote, Joy M; Ramirez-Mondragon, Carlos A; Siegel, Zarek S et al. (2017) The Stories Tryptophans Tell: Exploring Protein Dynamics of Heptosyltransferase I from Escherichia coli. Biochemistry 56:886-895
Abaci, H E; Guo, Zongyou; Doucet, Yanne et al. (2017) Next generation human skin constructs as advanced tools for drug development. Exp Biol Med (Maywood) 242:1657-1668
Kaplan, Anne R; Kaus, Katherine; De, Swastik et al. (2017) NMR structure of the Bacillus cereus hemolysin II C-terminal domain reveals a novel fold. Sci Rep 7:3277
Thayer, Kelly M; Lakhani, Bharat; Beveridge, David L (2017) Molecular Dynamics-Markov State Model of Protein Ligand Binding and Allostery in CRIB-PDZ: Conformational Selection and Induced Fit. J Phys Chem B 121:5509-5514
Lakhani, Bharat; Thayer, Kelly M; Hingorani, Manju M et al. (2017) Evolutionary Covariance Combined with Molecular Dynamics Predicts a Framework for Allostery in the MutS DNA Mismatch Repair Protein. J Phys Chem B 121:2049-2061
Moreno, Andrew; Knee, J L; Mukerji, Ishita (2016) Photophysical Characterization of Enhanced 6-Methylisoxanthopterin Fluorescence in Duplex DNA. J Phys Chem B 120:12232-12248
Wang, Wujie; Nocka, Laura M; Wiemann, Brianne Z et al. (2016) Holliday Junction Thermodynamics and Structure: Coarse-Grained Simulations and Experiments. Sci Rep 6:22863
Zhang, Qi; Li, Yan; Olson, Rich et al. (2016) Conserved SecA Signal Peptide-Binding Site Revealed by Engineered Protein Chimeras and Förster Resonance Energy Transfer. Biochemistry 55:1291-300
De, Swastik; Bubnys, Adele; Alonzo 3rd, Francis et al. (2015) The Relationship between Glycan Binding and Direct Membrane Interactions in Vibrio cholerae Cytolysin, a Channel-forming Toxin. J Biol Chem 290:28402-15

Showing the most recent 10 out of 27 publications