Molecular biophysics at the University of Pennsylvania has a long and rich history. Eldridge Reeves Johnson, the former president of the Victor Talking Machine Company (RCA), gave the University a generous endowment in 1927 to establish first organization in this country dedicated to medical physics. The Johnson Foundation (JF) was established for the """"""""study and development of physical methods in the investigation of disease and in its cure."""""""" Under the initial leadership of Detlev Bronk and then Britton Chance, the JF established Penn as a world-center for physical biochemistry and biophysics. Investigators in the JF expanded methods for studying action potentials, developed innovative techniques of biological oxygen detection, introduced a range of instrumentation for study of fast reactions, explored applications of new technologies such as ultrasound, electron microscopy, EPR, NMR and MRI. The Johnson Foundation, now under the direction of P. Leslie Dutton, has continued to evolve and expand into structural and computational biology, high-resolution NMR spectroscopy, protein dynamics &folding and single molecule approaches to a variety of fundamental questions in human biology. The JF is centered in a dynamic department of Biochemistry &Biophysics that is focused on quantitative biochemistry and biophysics. It is in this strong framework that the training program in Structural Biology and Molecular Biophysics promotes the application of structural biology and molecular biophysics to clinically relevant research. It is the flagship predoctoral training program for quantitative biology in the medical school and arguably for the entire University. The fundamental goal of our training mission is to produce biophysicists who can effectively integrate and apply the physical methodologies to medically relevant research problems. Our program explicitly integrates human biology and pathology into the graduate curriculum. The SBMB training program is designed to produce well-rounded scientists with expertise in structural biology and biophysics as well as have a solid foundation in biomedical sciences and disease. Historically, our trainees come to the program with diverse educational backgrounds that range from physics, chemistry, biology, engineering and biochemistry, even pure math. To accommodate this diversity, the training program provides extensive flexibility in the construction of personalized curricula. The research resources offered by the University of Pennsylvania are matched by few universities in the world. Importantly, the fact that all schools of the University are located on one contiguous campus provides a significant advantage for collaborative interactions across disciplines, something that is important to structural biology and molecular biophysics. The faculty provided by this training program are creative, well-funded investigators with a demonstrable track-record of teaching and mentorship. With the emergence of translational medicine as a priority it seems a priority to maintain a broadly educated capability in structural biology and molecular biophysics and, with this in mind, the program at the University of Pennsylvania is designed to produce well- trained and synoptically thinking biophysical scientists.
Basic research in structural biology and molecular biophysics provides the foundation upon which modern medicine rests. This training program in structural biology and molecular biophysics seeks to provide a creative and comprehensive environment for training the leaders of the future. It will do so by sustaining a rigorous program in these ares while providing a strong biomedical context. The emphasis on quantitative aspects of biology is both timely and necessary to maintain the strength of the United States'leadership in biomedical research.
|Walters, Christopher R; Ferrie, John J; Petersson, E James (2018) Dithioamide substitutions in proteins: effects on thermostability, peptide binding, and fluorescence quenching in calmodulin. Chem Commun (Camb) 54:1766-1769|
|Sutherland, George A; Grayson, Katie J; Adams, Nathan B P et al. (2018) Probing the quality control mechanism of the Escherichia coli twin-arginine translocase with folding variants of a de novo-designed heme protein. J Biol Chem 293:6672-6681|
|O'Brien, Evan S; Lin, Danny W; Fuglestad, Brian et al. (2018) Improving yields of deuterated, methyl labeled protein by growing in H2O. J Biomol NMR 71:263-273|
|Vara, Brandon A; Li, Xingpin; Berritt, Simon et al. (2018) Scalable thioarylation of unprotected peptides and biomolecules under Ni/photoredox catalysis. Chem Sci 9:336-344|
|Caro, José A; Wand, A Joshua (2018) Practical aspects of high-pressure NMR spectroscopy and its applications in protein biophysics and structural biology. Methods 148:67-80|
|Bagchi, Atrish; Haidar, Jaafar N; Eastman, Scott W et al. (2018) Molecular Basis for Necitumumab Inhibition of EGFR Variants Associated with Acquired Cetuximab Resistance. Mol Cancer Ther 17:521-531|
|Yuan, Zuo-Fei; Sidoli, Simone; Marchione, Dylan M et al. (2018) EpiProfile 2.0: A Computational Platform for Processing Epi-Proteomics Mass Spectrometry Data. J Proteome Res 17:2533-2541|
|Guo, Lin; Kim, Hong Joo; Wang, Hejia et al. (2018) Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell 173:677-692.e20|
|Armour, Sean M; Remsberg, Jarrett R; Damle, Manashree et al. (2017) An HDAC3-PROX1 corepressor module acts on HNF4? to control hepatic triglycerides. Nat Commun 8:549|
|Das, Arunika; Smoak, Evan M; Linares-Saldana, Ricardo et al. (2017) Centromere inheritance through the germline. Chromosoma 126:595-604|
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