The goal of the Molecular Biophysics (MB) Training Program is to prepare highly qualified students for research careers in molecular biophysics and computational biology, areas that will serve the explosive growth of technology and computation/bioinformatics in biological and medical research. Trainees can choose from a substantial and highly diverse group of faculty research mentors (30) with projects in many areas of high national priority. The training program attracts a highly qualified and geographically diverse group of students. We are striving to improve the representation of minority students through a number of efforts. In addition to direct faculty involvement in recruiting trips to minority institutions and conferences, minority trainees have recently founded the Organization for Under-Represented Scientists (OURS) to enhance their own role. Following the reorganization of the life sciences, resources were made available to build in several areas of particular relevance to the MB training program, including structural biology and bioinformatics. The University has also built at the interface of biology, chemistry and physics through new hires in Chemistry and Physics. These efforts have added several outstanding new faculty to the program. The program gives students full access to all participating faculty and facilities of the institution while providing them with the supportive atmosphere of relatively small departments. New developments in the program include standardized rotations through research labs when the trainees first enter the program, a course in scientific ethics and monthly trainee presentations. The trainee-organized annual symposium continues to be a high point of each year. The new Chemical and Life Sciences Laboratory was occupied in 1998, and an $80 million Post-genomics Institute has been approved by the State legislature. World class research support facilities are available in the Biotechnology Center (nucleotide and protein sequencing, amino acid analysis, oligonucleotide and peptide synthesis, DNA array technology, production of hybridomas, polyclonal antibodies and transgenic animals, flow cytometry, fermentation), Chemical Sciences Service Facilities (NMR, ESR, mass spectrometry), Beckman Institute (imaging and electron microscopy), and the National Center for Supercomputing Applications. The University of Illinois Libarary is the 3rd largest academic library in the nation, with sub-libraries in biology, chemistry, and medicine in very close proximity.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008276-18
Application #
6915605
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
1988-09-30
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
18
Fiscal Year
2005
Total Cost
$384,148
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Mahinthichaichan, Paween; Morris, Dylan M; Wang, Yi et al. (2018) Selective Permeability of Carboxysome Shell Pores to Anionic Molecules. J Phys Chem B 122:9110-9118
Mahinthichaichan, Paween; Gennis, Robert B; Tajkhorshid, Emad (2018) Cytochrome aa3 Oxygen Reductase Utilizes the Tunnel Observed in the Crystal Structures To Deliver O2 for Catalysis. Biochemistry 57:2150-2161
Mahinthichaichan, Paween; Gennis, Robert B; Tajkhorshid, Emad (2018) Bacterial denitrifying nitric oxide reductases and aerobic respiratory terminal oxidases use similar delivery pathways for their molecular substrates. Biochim Biophys Acta Bioenerg 1859:712-724
Barclay, Alexander M; Dhavale, Dhruva D; Courtney, Joseph M et al. (2018) Resonance assignments of an ?-synuclein fibril prepared in Tris buffer at moderate ionic strength. Biomol NMR Assign 12:195-199
Reed, Julian H; Shi, Yelu; Zhu, Qianhong et al. (2017) Manganese and Cobalt in the Nonheme-Metal-Binding Site of a Biosynthetic Model of Heme-Copper Oxidase Superfamily Confer Oxidase Activity through Redox-Inactive Mechanism. J Am Chem Soc 139:12209-12218
Desai, Janish; Liu, Yi-Liang; Wei, Hongli et al. (2016) Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase. ChemMedChem 11:1915-23
Tuttle, Marcus D; Comellas, Gemma; Nieuwkoop, Andrew J et al. (2016) Solid-state NMR structure of a pathogenic fibril of full-length human ?-synuclein. Nat Struct Mol Biol 23:409-15
Tuttle, Marcus D; Courtney, Joseph M; Barclay, Alexander M et al. (2016) Preparation of Amyloid Fibrils for Magic-Angle Spinning Solid-State NMR Spectroscopy. Methods Mol Biol 1345:173-83
Sun, Chang; Taguchi, Alexander T; Vermaas, Josh V et al. (2016) Q-Band Electron-Nuclear Double Resonance Reveals Out-of-Plane Hydrogen Bonds Stabilize an Anionic Ubisemiquinone in Cytochrome bo3 from Escherichia coli. Biochemistry 55:5714-5725
Stone, John E; Hallock, Michael J; Phillips, James C et al. (2016) Evaluation of Emerging Energy-Efficient Heterogeneous Computing Platforms for Biomolecular and Cellular Simulation Workloads. IEEE Int Symp Parallel Distrib Process Workshops Phd Forum 2016:89-100

Showing the most recent 10 out of 82 publications