The Molecular Biophysics Training Grant at Harvard University supports a predoctoral training program focused at the interface of physical and biological sciences. The goal of the program is to provide students with strong undergraduate backgrounds in quantitative sciences (especially physics and mathematics) with broad training in the biophysical, chemical and molecular concepts and techniques that are required to address outstanding problems in biology and biomedical sciences. The training program links a highly interactive group of 51 faculty members from four departments in Harvard's Faculty of Arts and Sciences, the School of Engineering and Applied Sciences, six departments at Harvard Medical School, and five affiliated hospitals. The training program offers a flexible curriculum drawn from courses offered at Harvard, Harvard Medical School and Massachusetts Institute of Technology (MIT), and research opportunities in a variety of disciplines relevant to molecular biophysics with particular strengths in the areas of structural biology, computational biology, quantitative cell biology, single molecule biophysics, neuroscience, and imaging. In addition to coursework and research activities, the training program sponsors seminars and guest lectures; a student-run research seminar series; a yearly offsite research retreat in the Fall that includes student and faculty research talks, a plenary lecture and a poster session featuring research of program students; a mini-symposium featuring talks by program faculty as well as a student poster session during the Biophysics Program recruitment weekend in the Spring term; and social events for all trainees. Over the past 29 years, this training program has helped foster a number of new initiatives in graduate training, and has been remarkably successful in promoting collaborative research among its faculty and interdisciplinary training for its students spanning all of Harvard and some of MIT. In this competing renewal, we request support for 16 training slots for students who are affiliated with Harvard's Biophysics Program or who are jointly affiliated with the Harvard Biophysics Program and Medical Engineering and Medical Physics Ph.D. program in the joint Harvard/ MIT Health Sciences and Technology initiative. Students will be preferentially funded in their first and second year of graduate studies.

Public Health Relevance

This training program offers interdisciplinary training at the interface between biology and physics, focusing on approaches to explore the structure, function and interactions of key macromolecules of the cell, the control of cellular and multicellular processes at the molecular and genome-wide levels, as well as the development of methods to image and model these processes. Trainees will also learn to ultimately use this information to diagnose, understand, prevent or cure human diseases. !

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Flicker, Paula F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Harvard University
Schools of Arts and Sciences
United States
Zip Code
Stolte, Björn; Iniguez, Amanda Balboni; Dharia, Neekesh V et al. (2018) Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. J Exp Med 215:2137-2155
Wang, Songyu; Powers, Robert E; Gold, Vicki Am et al. (2018) The ER morphology-regulating lunapark protein induces the formation of stacked bilayer discs. Life Sci Alliance 1:e201700014
Lin, Jia-Ren; Izar, Benjamin; Wang, Shu et al. (2018) Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. Elife 7:
Kimchi, Ofer; Veatch, Sarah L; Machta, Benjamin B (2018) Ion channels can be allosterically regulated by membrane domains near a de-mixing critical point. J Gen Physiol 150:1769-1777
Jenkins, Russell W; Aref, Amir R; Lizotte, Patrick H et al. (2018) Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov 8:196-215
Harris, Nicholas C; Born, David A; Cai, Wenlong et al. (2018) Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase. Angew Chem Int Ed Engl 57:9707-9710
Bitran, Amir; Chiang, Wei-Yin; Levine, Erel et al. (2017) Mechanisms of fast and stringent search in homologous pairing of double-stranded DNA. PLoS Comput Biol 13:e1005421
Kim, Y Bill; Komor, Alexis C; Levy, Jonathan M et al. (2017) Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions. Nat Biotechnol 35:371-376
Wachter, F; Morgan, A M; Godes, M et al. (2017) Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting. Oncogene 36:2184-2190
Powers, Robert E; Gaudet, Rachelle; Sotomayor, Marcos (2017) A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15. Structure 25:482-495

Showing the most recent 10 out of 91 publications