The fundamental objective of our Trauma Research Training Program is to prepare surgical trainees for future basic investigation on morbidity and mortality following severe injury. This includes research into pathogenesis of organ dysfunction in survivors of severe injury, as well as the mechanisms of early mortality (e.g. coagulopathy). The secondary objective is to inspire surgical trainees to pursue an academic career in trauma surgery. The rationale for this Program is the fact that trauma continues to be the leading cause of death in the US for individuals between the ages of 1 - 45 of age, and the societal costs attributed to trauma exceed those of cancer and heart disease. The design of the Program is a full-time commitment to basic investigation conducted primarily in two well-established surgery laboratories at the University of Colorado Denver (UCD) supplemented with patient data from clinical research in a regional Level 1 Trauma Center at the Denver Health and Hospital Authority (DHHA) and UCD. Relevant experiments will be performed in additional laboratories that focus on characterizing metabolomics and proteomics. The principal animal model will consist of hemorrhagic shock and tissue injury, and the basic investigation will include therapeutic modulation of inflammation. The fellow will commence their participation in the Program typically after their second or third year of surgical training (PGY 2 or 3), and will be dedicated exclusively to the Program for two years. We are requesting funding for five positions, sequenced so that there are first year and second year fellows assigned to each of the core laboratories.

Public Health Relevance

Trauma due to mechanical injury consumes more societal resources than cancer and heart disease. The primary objective of our Program is to prepare and inspire surgery trainees to pursue professional careers that encompass basic investigation of the fundamental mechanisms responsible for death and disability following trauma.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZGM1)
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Somers, Scott D
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University of Colorado Denver
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United States
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Stettler, Gregory R; Sumislawski, Joshua J; Moore, Ernest E et al. (2018) Citrated kaolin thrombelastography (TEG) thresholds for goal-directed therapy in injured patients receiving massive transfusion. J Trauma Acute Care Surg 85:734-740
Coleman, Julia R; Moore, Ernest E; Chapman, Michael P et al. (2018) Rapid TEG efficiently guides hemostatic resuscitation in trauma patients. Surgery 164:489-493
Banerjee, Anirban; Silliman, Christopher C; Moore, Ernest E et al. (2018) Systemic hyperfibrinolysis after trauma: a pilot study of targeted proteomic analysis of superposed mechanisms in patient plasma. J Trauma Acute Care Surg 84:929-938
Moore, Ernest E; Moore, Hunter B; Chapman, Michael P et al. (2018) Goal-directed hemostatic resuscitation for trauma induced coagulopathy: Maintaining homeostasis. J Trauma Acute Care Surg 84:S35-S40
Reisz, Julie A; Wither, Matthew J; Moore, Ernest E et al. (2018) All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients. J Trauma Acute Care Surg 84:537-541
Samuels, Jason M; Moore, Hunter B; Moore, Ernest E (2018) Coagulopathy in Severe Sepsis: Interconnectivity of Coagulation and the Immune System. Surg Infect (Larchmt) 19:208-215
Stettler, Gregory R; Moore, Ernest E; Nunns, Geoffrey R et al. (2018) Rotational thromboelastometry thresholds for patients at risk for massive transfusion. J Surg Res 228:154-159
Lawson, Peter J; Moore, Hunter B; Moore, Ernest E et al. (2018) Microfluidics contrasted to thrombelastography: perplexities in defining hypercoagulability. J Surg Res 231:54-61
Nunns, Geoffrey R; Stringham, John R; Gamboni, Fabia et al. (2018) Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue. J Surg Res 229:262-270
Moore, Hunter B; Paniccia, Alessandro; Lawson, Peter J et al. (2018) Utility of Viscoelastic Assays Beyond Coagulation: Can Preoperative Thrombelastography Indices Predict Tumor Histology, Nodal Disease, and Resectability in Patients Undergoing Pancreatectomy? J Am Coll Surg 227:55-62

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