This revised application requests continuing support for a training program which provides graduate students studying for the PhD degree with broad state-of-the-art training in Systems and Integrative Biology. Students will learn and apply tools and approaches of genomics, bioinformatics, proteomics as well as cell and molecular biology to the study of integrated systems and organismic biology. The program is centered in the Department of Molecular &Integrative Physiology because of its longstanding commitment to integrative biology but students will enter from an initial year in a combined gateway Program in Biomedical Sciences (PIBS) and can be enrolled in multiple PhD programs including Physiology, Pharmacology, Neuroscience, Bioinformatics and Human Genetics. Trainees will usually be supported for two years. The potential applicant pool is all students applying to PIBS and includes both students who come to Michigan to study integrative biology and those who enter undecided and are then drawn to integrative biology. The training includes formal coursework and seminars, teaching, and research experiences with faculty in a variety of departments at the University of Michigan. All students will take graduate level courses in Integrative Biology, Cell and Molecular function, Molecular Biology and Genetics, and Computational Biology. Additional courses are selected by the student in accordance with his/her interests. Students also participate in weekly student research seminars in their PhD program which they are expected to critically evaluate the presentations of their peers. This broad training is further reinforced by each student taking a written preliminary examination at the end of the second year of study that requires and understanding of function, from the cellular and molecular level to that of the organism including interactions between the environment and the organism. A unique aspect of the proposed training is that all students will have two dissertation co-chairs, rather than the more traditional single chair, at least one of whom will be schooled in the most recent techniques in cellular, molecular, or computational biology and one being an integrative biologist. The training faculty consists of 58 outstanding scientists all of whom are expert in either cellular and molecular or systems and integrative biology and committed to training individuals to answer questions of integrative physiological relevance.

Public Health Relevance

This training grant will increase the number of scientists trained in systems and integrative biology. This area is important as it prepares scientists to participate in translational work on health and disease.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Maas, Stefan
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
Zip Code
Hedges, Valerie L; Chen, Gang; Yu, Lei et al. (2018) Local Estrogen Synthesis Regulates Parallel Fiber-Purkinje Cell Neurotransmission Within the Cerebellar Cortex. Endocrinology 159:1328-1338
Cho, Chun-Seok; Park, Hwan-Woo; Ho, Allison et al. (2018) Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation. Hepatology 68:1331-1346
Bouza, Alexandra A; Isom, Lori L (2018) Voltage-Gated Sodium Channel ? Subunits and Their Related Diseases. Handb Exp Pharmacol 246:423-450
Hull, Jacob M; Isom, Lori L (2018) Voltage-gated sodium channel ? subunits: The power outside the pore in brain development and disease. Neuropharmacology 132:43-57
Schnell, Santiago (2018) ""Reproducible"" Research in Mathematical Sciences Requires Changes in our Peer Review Culture and Modernization of our Current Publication Approach. Bull Math Biol 80:3095-3105
Caselli, Emilia; Romagnoli, Chiara; Powers, Rachel A et al. (2018) Inhibition of Acinetobacter-Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel ?-Lactamase Inhibitors. ACS Infect Dis 4:337-348
Bouza, Alexandra A; Swanson, Hollister C; Smolen, Kali A et al. (2018) Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C ?-Lactamase. ACS Infect Dis 4:325-336
Namkoong, Sim; Ho, Allison; Woo, Yu Mi et al. (2018) Systematic Characterization of Stress-Induced RNA Granulation. Mol Cell 70:175-187.e8
Bodur, Cagri; Kazyken, Dubek; Huang, Kezhen et al. (2018) The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists. EMBO J 37:19-38
Uchida, Keita; Lopatin, Anatoli N (2018) Diffusional and Electrical Properties of T-Tubules Are Governed by Their Constrictions and Dilations. Biophys J 114:437-449

Showing the most recent 10 out of 178 publications