The mission of the NIGMS/MIT Biotechnology Training Program is to train leaders in the field of Biotechnology, drawing primarily from the fields of Biological Engineering, Chemical Engineering, and Chemistry. The American Heritage Dictionary defines Biotechnology as: """"""""The application of the principles of engineering and technology to the life sciences;bioengineering."""""""" Information productively flows in both directions: new technologies enable the discovery of new biology, and the discovery of new biology enables new technologies. The MIT BTP encompasses research in the fields of Bioprocess Engineering, Metabolic Engineering, Tissue Engineering, Biomolecular Design, Cellular Bioengineering, BioMEMS, Systems Biology, and more. A major aim of the MIT BTP is to broaden the students'graduate training by a program that repeatedly puts them in close contact with students and faculty from other disciplines. Trainees are appointed at the end of their first year of graduate studies, and their stipend is supported by the BTP for three years, during which they complete the following requirements: i) a) two biotechnology courses outside their home department and b) one interdisciplinary course from a restricted list;ii) Monthly BTP meetings for research updates;iii) Attendance &poster presentation at an Annual Retreat, one full day in April;iv) Training in responsible conduct of research;and v) An industrial internshipof 2-3 months. At present 19 predoctoral trainees are appointed to the program at any given time, but given the strong nominee pool and only a 58% success rate for highly qualified nominations to the program, an increase in support to 22 trainees is requested. Over 200 trainees have benefited from the program during the 24 years of existence of the NIGMS/MIT BTP, and many have risen to positions of prominence in both academics and industry. We contacted selected alumni of the program to gain their perspectives on the influence the BTP had on their career development, and numerous successful individuals cite this highly interdisciplinary program and peer network as a critical formative experience. Excerpts of these comments are included in this proposal.

Public Health Relevance

The NIGMS/MIT Biotechnology Training Program prepares outstanding Ph.D. candidates from science and engineering for leadership in the interdisciplinary field of Biotechnology. Biotechnology largely consists of the application of new life science technologies to improved therapeutics and diagnostics, although there are also growing efforts in the fields of energy, environment, and microelectronics. Graduates of this program over the past 24 years have had tremendous impact in both academics and the biotechnology industry.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM008334-26
Application #
8608223
Study Section
(TWD)
Program Officer
Gerratana, Barbara
Project Start
1989-09-27
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
26
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Engineering (All Types)
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02142
Freedman, Adam J E; Peet, Kyle C; Boock, Jason T et al. (2018) Isolation, Development, and Genomic Analysis of Bacillus megaterium SR7 for Growth and Metabolite Production Under Supercritical Carbon Dioxide. Front Microbiol 9:2152
Miller, Eric A; Baniya, Subha; Osorio, Daniel et al. (2018) Paper-based diagnostics in the antigen-depletion regime: High-density immobilization of rcSso7d-cellulose-binding domain fusion proteins for efficient target capture. Biosens Bioelectron 102:456-463
Kelly, Ryan L; Le, Doris; Zhao, Jessie et al. (2018) Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries. J Mol Biol 430:119-130
Hsu, Tammy M; Welner, Ditte H; Russ, Zachary N et al. (2018) Employing a biochemical protecting group for a sustainable indigo dyeing strategy. Nat Chem Biol 14:256-261
Co, Julia Y; Cárcamo-Oyarce, Gerardo; Billings, Nicole et al. (2018) Mucins trigger dispersal of Pseudomonas aeruginosa biofilms. NPJ Biofilms Microbiomes 4:23
Kumar, Manu P; Du, Jinyan; Lagoudas, Georgia et al. (2018) Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics. Cell Rep 25:1458-1468.e4
Wittenborn, Elizabeth C; Merrouch, Mériem; Ueda, Chie et al. (2018) Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase. Elife 7:
Kedaigle, Amanda J; Fraenkel, Ernest (2018) Discovering Altered Regulation and Signaling Through Network-based Integration of Transcriptomic, Epigenomic, and Proteomic Tumor Data. Methods Mol Biol 1711:13-26
Edington, Collin D; Chen, Wen Li Kelly; Geishecker, Emily et al. (2018) Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies. Sci Rep 8:4530
Doong, Stephanie J; Gupta, Apoorv; Prather, Kristala L J (2018) Layered dynamic regulation for improving metabolic pathway productivity in Escherichia coli. Proc Natl Acad Sci U S A 115:2964-2969

Showing the most recent 10 out of 201 publications