The objective of this program is to train pharmaceutical scientists to handle the development of products arising from biotechnology research (i.e., therapeutic drugs and vaccines). Due to the difficulty and complex nature of developing biotechnology-derived drugs, it is necessary to train a new """"""""breed"""""""" of pharmaceutical scientists who can respond to the need for interdisciplinary approaches for the advancement of biological, chemical, and pharmaceutical sciences by integrating mathematics, physics, biology, molecular biology, and chemistry to solve difficult problems in designing therapeutic agents of the future. This new type of scientist could also be employed in academic institutions to expand the educational training of future pharmaceutical biotechnology scientists. This training program has been in existence for 26 years with 37 faculty mentors and eight students will be in the training program. There are three major areas of research in this training program: (1) the traditional """"""""pharmaceutics"""""""" area that includes formation, analysis, and delivery, (2) the protein structure and bioinformatics area, and (3) the vaccine stabilization and formulation area. The 37 faculty mentors are from various departments (e.g., Chemistry, Medicinal Chemistry, Mechanical Engineering, Molecular Biosciences, and Pharmaceutical Chemistry, etc.) and Centers (Adams Institute for Bioanalytical Chemistry, Bioengineering and Bioinformatics Centers). The Steering Committee oversees all aspects of the Biotechnology Training Program;Drs. Siahaan and Volkin serve as the PI and Co-PI of the program, respectively. The students will be selected from a pool of applicants that are nominated by the faculty mentors from the participating departments. The Steering Committee will select the trainees from the nominated students each year. The trainees have to take required and elective courses for the training program including a course on responsible conduct in research. The students are also required to do 3-6 months industrial internship. The students'progress will be monitored in quarterly meetings and annual KU retreat. The trainees organize the Joint CU-KU Symposia, which is a joint symposium with the Biotechnology Training Program at the University of Colorado. The trainees will be supported by the training program for a maximum of two years. The alumni of this program who have been working for five years in industry and academia will be invited to present their research at the yearly KU retreat as well as to provide feedback on the training program.

Public Health Relevance

The mission of the training program is to produce future scientists that will work in the area of pharmaceutical biotechnology to support development of biotechnology products (i.e., therapeutic drugs and vaccines) for improving human health in US and globally.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM008359-24A1
Application #
8742968
Study Section
(TWD)
Program Officer
Gerratana, Barbara
Project Start
1989-09-27
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
24
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Lawrence
State
KS
Country
United States
Zip Code
66045
More, Apurva S; Toth 4th, Ronald T; Okbazghi, Solomon Z et al. (2018) Impact of Glycosylation on the Local Backbone Flexibility of Well-Defined IgG1-Fc Glycoforms Using Hydrogen Exchange-Mass Spectrometry. J Pharm Sci 107:2315-2324
Toth 4th, Ronald T; Pace, Samantha E; Mills, Brittney J et al. (2018) Evaluation of Hydrogen Exchange Mass Spectrometry as a Stability-Indicating Method for Formulation Excipient Screening for an IgG4 Monoclonal Antibody. J Pharm Sci 107:1009-1019
Mills, Brittney J; Laurence Chadwick, Jennifer S (2018) Effects of localized interactions and surface properties on stability of protein-based therapeutics. J Pharm Pharmacol 70:609-624
Franklin, Meghan Whitney; Nepomnyachiy, Sergey; Feehan, Ryan et al. (2018) Efflux Pumps Represent Possible Evolutionary Convergence onto the ?-Barrel Fold. Structure 26:1266-1274.e2
Machen, Alexandra J; O'Neil, Pierce T; Pentelute, Bradley L et al. (2018) Analyzing Dynamic Protein Complexes Assembled On and Released From Biolayer Interferometry Biosensor Using Mass Spectrometry and Electron Microscopy. J Vis Exp :
Franklin, Meghan Whitney; Slusky, Joanna S G (2018) Tight Turns of Outer Membrane Proteins: An Analysis of Sequence, Structure, and Hydrogen Bonding. J Mol Biol 430:3251-3265
Wei, Yangjie; Xiong, Jian; Larson, Nicholas R et al. (2018) Effect of 2 Emulsion-Based Adjuvants on the Structure and Thermal Stability of Staphylococcus aureus Alpha-Toxin. J Pharm Sci 107:2325-2334
Knewtson, Kelsey E; Rane, Digamber; Peterson, Blake R (2018) Targeting Fluorescent Sensors to Endoplasmic Reticulum Membranes Enables Detection of Peroxynitrite During Cellular Phagocytosis. ACS Chem Biol 13:2595-2602
Pace, Samantha E; Joshi, Sangeeta B; Esfandiary, Reza et al. (2018) The Use of a GroEL-BLI Biosensor to Rapidly Assess Preaggregate Populations for Antibody Solutions Exhibiting Different Stability Profiles. J Pharm Sci 107:559-570
Dennis, S Connor; Whitlow, Jonathan; Detamore, Michael S et al. (2017) Hyaluronic-Acid-Hydroxyapatite Colloidal Gels Combined with Micronized Native ECM as Potential Bone Defect Fillers. Langmuir 33:206-218

Showing the most recent 10 out of 105 publications