We seek renewal of our long-standing biotechnology training program, which has a history of producing accomplished leaders in academia and industry. Biotechnology is broadening and maturing as a field with an expansion of knowledge, methods, and applications. In parallel, industry has been shaping a new field focused on biotechnology for prevention, diagnosis, and treatment of disease. Now, more than ever before, interdisciplinary training and awareness is critically needed for biotechnologists to be optimally productive and to make an impact on the world. Stanford provides an unusually rich biotechnology environment, with co- located, nationally ranked schools devoted to basic science, engineering, and medicine, and a strong industrial presence from the surrounding Bay Area. We will leverage this environment to train talented students who will become the next-generation of global biotechnology innovators and leaders. The program fuses 28 investigators from 8 departments across the university into a highly visible program to deliver a rich, applications-oriented training experience that is uniquely focused on health-related biotechnology. Many unique features differentiate this training program, including rich curricular offerings, industrial internships, field trips, biotechnology symposia, and regular and detailed interactions with other trainees and with academic and industrial mentors. Guided by input from faculty, trainees, NIH officials, and industrial affiliates, we evolved a more cohesive training program by implementing a sharper focus on synthetic biology, pharmaceutical discovery and development, and advancements in tools and technologies related to these areas. This evolution recognizes dramatic faculty expansion and new initiatives at Stanford toward these pursuits and has motivated major changes in preceptor appointment to the training program.

Public Health Relevance

The objective of the program is to provide a highly enriched, multi-disciplinary training experience in biotechnology for predoctoral students from a broad variety of departments across the university. Program components, which include coursework, mentored research experiences, and industry engagement, provide a unique mechanism for training talented students who will become the next-generation of global biotechnology innovators and leaders.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008412-25
Application #
9986816
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Brown, Patrick
Project Start
1991-07-01
Project End
2021-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
25
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Stanford University
Department
Biomedical Engineering
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Mitchell, Aaron C; Alford, Spencer C; Hunter, Sean A et al. (2018) Development of a Protease Biosensor Based on a Dimerization-Dependent Red Fluorescent Protein. ACS Chem Biol 13:66-72
Mitchell, Aaron C; Kannan, Deepti; Hunter, Sean A et al. (2018) Engineering a potent inhibitor of matriptase from the natural hepatocyte growth factor activator inhibitor type-1 (HAI-1) protein. J Biol Chem 293:4969-4980
Toda, Satoshi; Blauch, Lucas R; Tang, Sindy K Y et al. (2018) Programming self-organizing multicellular structures with synthetic cell-cell signaling. Science 361:156-162
Blauch, Lucas R; Gai, Ya; Khor, Jian Wei et al. (2017) Microfluidic guillotine for single-cell wound repair studies. Proc Natl Acad Sci U S A 114:7283-7288
Ly, Nina; Cyert, Martha S (2017) Calcineurin, the Ca2+-dependent phosphatase, regulates Rga2, a Cdc42 GTPase-activating protein, to modulate pheromone signaling. Mol Biol Cell 28:576-586
Steele, Amanda N; Cai, Lei; Truong, Vi N et al. (2017) A novel protein-engineered hepatocyte growth factor analog released via a shear-thinning injectable hydrogel enhances post-infarction ventricular function. Biotechnol Bioeng 114:2379-2389
Bisaria, Namita; Greenfeld, Max; Limouse, Charles et al. (2017) Quantitative tests of a reconstitution model for RNA folding thermodynamics and kinetics. Proc Natl Acad Sci U S A 114:E7688-E7696
Kariolis, Mihalis S; Miao, Yu Rebecca; Diep, Anh et al. (2017) Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest 127:183-198
Hahn, Aria S; Altman, Tomer; Konwar, Kishori M et al. (2017) A geographically-diverse collection of 418 human gut microbiome pathway genome databases. Sci Data 4:170035
Suarez, Sophia L; Muñoz, Adam; Mitchell, Aaron et al. (2016) Degradable acetalated dextran microparticles for tunable release of an engineered hepatocyte growth factor fragment. ACS Biomater Sci Eng 2:197-204

Showing the most recent 10 out of 45 publications