Trauma and sepsis are among the most important causes of morbidity and mortality in humans. The Pitt Trauma Research Training Program (Pitt TRTP) is focused on the training of physician-scientists and talented full-time PhDs in trauma, sepsis, and related pathobiological process including ischemia/reperfusion injury and wound healing. Progress in complex clinical fields such as trauma and sepsis requires investigative teams collectively possessing skills in diverse areas of research. These specialized research areas include, systems and computational biology, bench/translational research, and health services research, and thus require scientists capable of managing and evaluating large clinical data sets, other scientists facile with in silico simulations and computational strategies, other investigators skilled in reverse translating clinical observations into relevant preclinical models (both small and large animals), and finally, investigators well- versed in the design and execution of clinical trials in acutely ill trauma/surgical patients. To address these inter- and multidisciplinary needs, we have organized the Pitt TRTP around three core tracks: 1) the Surgical Outcomes, Health Services and Policy (SOHSP) Track; 2) The Systems Biology Track; and 3) the Bench/Translational Research Track. A Director with demonstrated expertise oversees each track, which in turn consists of expert faculty fully engaged with the program. These investigators have worked together for many years in collaborative, multidisciplinary teams. The Pitt TRTP leverages extensive local resources at the University of Pittsburgh School of Medicine, including robust clinical and research programs in trauma, acute care surgery, Surgical Critical Care, and sepsis research; world-class clinical programs (from which the patient data and biobanks are procured), including three Level Trauma Centers which admit over 8,000 trauma and 4000 acute care surgery patients per year as well as carrying out multiple clinical trials in the setting of trauma and sepsis; collaborating departments with international expertise in computational and systems biology along with immunology; and extensive core facilities which support current- and next-generation ?omics? research.

Public Health Relevance

By receiving dual training, these ?hybrid? surgeon-investigators will be equipped to not only identify the most pressing questions at the bedside, but to make discoveries that will underlie improvement in the care of the critically ill and injured patient.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Zhao, Xiaoli
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
Schools of Medicine
United States
Zip Code
Dyer, Mitchell R; Chen, Qiwei; Haldeman, Shannon et al. (2018) Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA. Sci Rep 8:2068
Lewis, Anthony J; Griepentrog, John E; Zhang, Xianghong et al. (2018) Prompt Administration of Antibiotics and Fluids in the Treatment of Sepsis: A Murine Trial. Crit Care Med 46:e426-e434
Lewis, Anthony J; Zhang, Xianghong; Griepentrog, John E et al. (2018) Blue Light Enhances Bacterial Clearance and Reduces Organ Injury During Sepsis. Crit Care Med 46:e779-e787
Brown, Joshua B; Gestring, Mark L; Leeper, Christine M et al. (2018) Characterizing injury severity in nonaccidental trauma: Does Injury Severity Score miss the mark? J Trauma Acute Care Surg 85:668-673
Xu, Jing; Guardado, Jesse; Hoffman, Rosemary et al. (2017) IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model. PLoS Med 14:e1002365
Lewis, Anthony; Zuckerbraun, Brian; Griepentrog, John et al. (2017) Reducing Animal Use with a Biotelemetry-Enhanced Murine Model of Sepsis. Sci Rep 7:6622
Brown, Joshua B; Rosengart, Matthew R; Billiar, Timothy R et al. (2017) Distance matters: Effect of geographic trauma system resource organization on fatal motor vehicle collisions. J Trauma Acute Care Surg 83:111-118
Shukla, M; Sekhon, U D S; Betapudi, V et al. (2017) In vitro characterization of SynthoPlate™ (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice. J Thromb Haemost 15:375-387
Zhang, Xianghong; Yuan, Du; Sun, Qian et al. (2017) Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis. FASEB J 31:4382-4395
Brown, Joshua B; Gestring, Mark L; Leeper, Christine M et al. (2017) The value of the injury severity score in pediatric trauma: Time for a new definition of severe injury? J Trauma Acute Care Surg 82:995-1001

Showing the most recent 10 out of 46 publications