The objective of this Chemistry-Biology Interface (CBI) Predoctoral Program is to provide cross- disciplinary training to talented students with diverse interests that will enable them to apply the mechanistic and atomistic perspective of chemistry to important biological problems. The program brings together forty outstanding faculty trainers from six academic units at the University of Delaware that represent diverse disciplines of organic chemistry, analytical chemistry, biochemistry, structural biology, molecular biology, cell biology, systems biology, bioinformatics, molecular biology, cell biology, plant biology, virology, and developmental biology. The faculty trainers include both new investigators and established researchers with vibrant research programs in biomolecular science and experience in training graduate students. Trainees with diverse undergraduate educational backgrounds are selected on the basis of their interests in interdisciplinary science, their GRE scores, undergraduate GPA and letters of recommendation. Five trainees are admitted each year through existing graduate programs of Chemistry & Biochemistry, Chemical & Biomolecular Engineering or Biological Sciences and supported in the CBI program for their first two years. Trainees will satisfy the degree requirements for their specific departmental program in addition to the requirements for the CBI program. Five one semester courses will be selected from a diverse list of course offerings from six departments. A key feature of the CBI program is the three laboratory rotations each trainee undertakes to provide them with hands-on experience in the different disciplines. Between courses and laboratory rotations students are expected to have exposure to concepts and methods from the atomistic to the cellular. All trainees are required to participate in a series of quarterly conduct of research (RCR) workshops. A weekly seminar series provides trainees numerous opportunities to present their own work, as well as learn from both faculty trainers and outside speakers. Each trainee undertakes an intensive independent research experience culminating in a dissertation representing an original contribution to a field at the chemistry-biology interface. This program follows a successful model for training scientists with both broad scientific knowledge as well as solid foundations in a chosen core discipline.

Public Health Relevance

Advances in molecular medicine are often impeded by traditional training paradigms in which chemists and biologists often do not speak the same scientific language nor understand advances in each other's fields. This CBI T32 program provides predoctoral trainees opportunities to learn to share ideas across traditionally separate fields in order to fertilize new ideas and innovations that require working knowledge of both chemistry and biology.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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Training and Workforce Development Subcommittee - D (TWD)
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Fabian, Miles
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University of Delaware
Schools of Arts and Sciences
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Drake, Walter R; Hou, Ching-Wen; Zachara, Natasha E et al. (2018) New use for CETSA: monitoring innate immune receptor stability via post-translational modification by OGT. J Bioenerg Biomembr 50:231-240
Lu, Manman; Sarkar, Sucharita; Wang, Mingzhang et al. (2018) 19F Magic Angle Spinning NMR Spectroscopy and Density Functional Theory Calculations of Fluorosubstituted Tryptophans: Integrating Experiment and Theory for Accurate Determination of Chemical Shift Tensors. J Phys Chem B 122:6148-6155
Liu, Jun; Chen, Qingqing; Rozovsky, Sharon (2018) Selenocysteine-Mediated Expressed Protein Ligation of SELENOM. Methods Mol Biol 1661:265-283
Franke, Karl R; Schmidt, Skye A; Park, Sunhee et al. (2018) Analysis of Brachypodium miRNA targets: evidence for diverse control during stress and conservation in bioenergy crops. BMC Genomics 19:547
Smith, Natalee J; Rohlfing, Katarina; Sawicki, Lisa A et al. (2018) Fast, irreversible modification of cysteines through strain releasing conjugate additions of cyclopropenyl ketones. Org Biomol Chem 16:2164-2169
DeMeester, Kristen E; Liang, Hai; Jensen, Matthew R et al. (2018) Synthesis of Functionalized N-Acetyl Muramic Acids To Probe Bacterial Cell Wall Recycling and Biosynthesis. J Am Chem Soc 140:9458-9465
Wang, Yiben; Lazor, Klare M; DeMeester, Kristen E et al. (2017) Postsynthetic Modification of Bacterial Peptidoglycan Using Bioorthogonal N-Acetylcysteamine Analogs and Peptidoglycan O-Acetyltransferase B. J Am Chem Soc 139:13596-13599
Schaefer, Amy K; Wastyk, Hannah C; Mohanan, Vishnu et al. (2017) Crohn's Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70. Biochemistry 56:4445-4448
Liang, Hai; DeMeester, Kristen E; Hou, Ching-Wen et al. (2017) Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications. Nat Commun 8:15015
Rehmann, Matthew S; Skeens, Kelsi M; Kharkar, Prathamesh M et al. (2017) Tuning and Predicting Mesh Size and Protein Release from Step Growth Hydrogels. Biomacromolecules 18:3131-3142

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