This National Research Service Award application seeks funds to continue a successful interdisciplinary training program in biophysics. Biophysicists with knowledge both of bio-systems and the tools of molecular biology but also of the tools and concepts of the physical sciences are increasingly in demand in the rapidly evolving biotechnology industry. The University of North Carolina at Chapel Hill (UNC-CH) is located at one apex of the Research Triangle, one of the world's principal centers of biotechnology research and development. The UNC Molecular and Cellular Biophysics Training Program (MCBP) channels the consider-able training resources of 38 faculty persons from 10 departments (Biochemistry &Biophysics, Biology, Cell Biology &Anatomy, Chemistry, Computer Science, Medicinal Chemistry, Microbiology, Pharmacology, Physiology, and Physics) at UNC-CH towards meeting North Carolina's and the nation's need for scientists trained in biophysics. The MCBP offers to a single cohort of graduate students the full spectrum of training opportunities provided by this diverse and excellent faculty.
The aims of the proposed training program are 1] to attract talented graduate students to apply the methods and concepts of the physical and quantitative sciences to key problems in biology;2] to provide a flexible vehicle for training this diverse group of graduate students;and 3] to foster interactions and enhance the training and research environment in the Research Triangle area. To accomplish these aims, an unique but flexible set of courses has been developed and blended with existing courses so as to allow trainees to satisfy individual departmental requirements for a Ph.D. that acknowledges Emphasis in Biophysics. Program-sponsored activities and research facilities encourage the existence of a vibrant and coherent biophysics community throughout the UNC-CH campus and the Research Triangle. This program of courses and training activities has been integrated with traditional departmental structures in a way that enhances but does not expand graduate training at UNC-CH.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Schools of Medicine
Chapel Hill
United States
Zip Code
Kirkpatrick, Christine L; Parsley, Nicole C; Bartges, Tessa E et al. (2018) Exploring bioactive peptides from bacterial secretomes using PepSAVI-MS: identification and characterization of Bac-21 from Enterococcus faecalis pPD1. Microb Biotechnol 11:943-951
Little, Michael S; Pellock, Samuel J; Walton, William G et al. (2018) Structural basis for the regulation of ?-glucuronidase expression by human gut Enterobacteriaceae. Proc Natl Acad Sci U S A 115:E152-E161
Patteson, Jon B; Cai, Wenlong; Johnson, Rachel A et al. (2018) Identification of the Biosynthetic Pathway for the Antibiotic Bicyclomycin. Biochemistry 57:61-65
Stadmiller, Samantha S; Pielak, Gary J (2018) The Expanding Zoo of In-Cell Protein NMR. Biophys J 115:1628-1629
Parsley, Nicole C; Kirkpatrick, Christine L; Crittenden, Christopher M et al. (2018) PepSAVI-MS reveals anticancer and antifungal cycloviolacins in Viola odorata. Phytochemistry 152:61-70
McLamarrah, Tiffany A; Buster, Daniel W; Galletta, Brian J et al. (2018) An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly. J Cell Biol 217:1217-1231
Hayne, Cassandra K; Yumerefendi, Hayretin; Cao, Lin et al. (2018) We FRET so You Don't Have To: New Models of the Lipoprotein Lipase Dimer. Biochemistry 57:241-254
Guseman, Alex J; Perez Goncalves, Gerardo M; Speer, Shannon L et al. (2018) Protein shape modulates crowding effects. Proc Natl Acad Sci U S A 115:10965-10970
Kudlacek, Stephan T; Premkumar, Lakshmanane; Metz, Stefan W et al. (2018) Physiological temperatures reduce dimerization of dengue and Zika virus recombinant envelope proteins. J Biol Chem 293:8922-8933
Studer, Sabine; Hansen, Douglas A; Pianowski, Zbigniew L et al. (2018) Evolution of a highly active and enantiospecific metalloenzyme from short peptides. Science 362:1285-1288

Showing the most recent 10 out of 96 publications