The specific aim of this competitive renewal of our training program in Trauma, Sepsis, Inflammation, and Critical Care is to develop physician/scientists who are well grounded in physiology, molecular biology, and molecular genetics. This program is designed to teach interested individuals to develop hypothesis-based research plans, enabling the trainees to transfer developments and new information from bench to bedside, leading to the development of novel and innovative therapeutic strategies in trauma and critical care. This training program is devoted to two years research training, and candidates for the training program must have an MD or PhD degree from an accredited medical or graduate school;only United States citizens or permanent residents are eligible. A two-year research commitment is required, and MD trainees are expected to have completed at least three years of postdoctoral training prior to beginning the fellowship. To achieve an understanding of the cellular and molecular mechanisms underlying organ failure in trauma and sepsis, trainees are placed in laboratories under the direction of scientific preceptors where state-of-the-art scientific methods are available and preceptors are committed to the training of physician/scientists. The inclusion of faculty from numerous departments across campus has produced a diverse program, and individuals selected as potential preceptors are nationally/internationally recognized scientists who have a long-term history of collaboration with investigators in the Department of Surgery. A diversity of research at UT Southwestern examines injury and inflammatory responses, enabling potential trainees to examine pathophysiologic mechanisms of trauma, sepsis, inflammation, and critical care. Trauma and sepsis constitute a major portion of health care costs in today's society. The development of clinical innovations that ultimately improve outcome of critically ill patients would be expected to reduce hospital stay and reduce the enormous financial burden that trauma and sepsis produce. Thus, the research and training described herein are particularly relevant to public health issues and concerns.
| Hodgman, Erica I; Subramanian, Madhu; Wolf, Steven E et al. (2017) The Effect of Illicit Drug Use on Outcomes Following Burn Injury. J Burn Care Res 38:e89-e94 |
| Song, Juquan; Saeman, Melody R; Baer, Lisa A et al. (2017) Exercise Altered the Skeletal Muscle MicroRNAs and Gene Expression Profiles in Burn Rats With Hindlimb Unloading. J Burn Care Res 38:11-19 |
| Subramanian, Madhu; Hranjec, Tjasa; Liu, Laindy et al. (2016) A case for less workup in near hanging. J Trauma Acute Care Surg 81:925-930 |
| Saeman, Melody R; DeSpain, Kevin; Liu, Ming-Mei et al. (2016) Severe burn increased skeletal muscle loss in mdx mutant mice. J Surg Res 202:372-9 |
| Saeman, Melody R; Hodgman, Erica I; Burris, Agnes et al. (2016) Epidemiology and outcomes of pediatric burns over 35 years at Parkland Hospital. Burns 42:202-208 |
| Hodgman, Erica I; Saeman, Melody R; Subramanian, Madhu et al. (2016) The Effect of Burn Center Volume on Mortality in a Pediatric Population: An Analysis of the National Burn Repository. J Burn Care Res 37:32-7 |
| Song, Juquan; Saeman, Melody R; De Libero, Jana et al. (2015) Skeletal Muscle Loss is Associated with TNF Mediated Insufficient Skeletal Myogenic Activation After Burn. Shock 44:479-86 |
| Saeman, Melody R; DeSpain, Kevin; Liu, Ming-Mei et al. (2015) Effects of exercise on soleus in severe burn and muscle disuse atrophy. J Surg Res 198:19-26 |
| Saeman, Melody R; Burkhalter, Lorrie S; Blackburn, Timothy J et al. (2015) Radiation exposure and safety practices during pediatric central line placement. J Pediatr Surg 50:992-5 |
| Brant, Sarah M; Cobert, Michael L; West, LaShondra M et al. (2014) Characterizing cardiac donation after circulatory death: implications for perfusion preservation. Ann Thorac Surg 98:2107-13; discussion 2113-4 |
Showing the most recent 10 out of 34 publications
