Abstract

The University of Michigan proposes to continue a predoctoral Chemistry-Biology Interface (CBI) Training Program for a selected group of Ph.D. students. The number of students requested for this new training program is 14 for a five-year period of support. The participating units are the Department of Chemistry, College of Literature, Science, and the Arts; the Departments of Biological Chemistry and Pharmacology, Medical School; the Biophysics Research Division (BRD); and the Department of Medicinal Chemistry, College of Pharmacy. The faculty of the CBI Training Program includes synthetic organic and inorganic chemists, bioorganic chemists, bioanalytical chemists, protein chemists, mechanistic enzymologists, spectroscopists, and crystallographers. The Ph.D. degrees will be awarded in Chemistry, Biological Chemistry, Pharmacology, and Medicinal Chemistry. Students will be appointed to the training grant for two ? years beginning in the second year of their Ph.D. program. The curriculum of the Training Program includes a novel student sabbatical to be completed while the trainee is supported by the training grant. Core courses in Chemical Biology and regularly scheduled opportunities for the trainees to present their research results to the Training Program Faculty and fellow trainees, are also integral to the program. ? ? Research opportunities for the trainees are varied and involve faculty with a wide range of expertise in research at the interface of chemistry and biology. The trainees have access to the most sophisticated techniques and instrumentation in modern research at this interface. The faculty of the Training Program has a long history of collaborative research and this interactive approach to research is a central theme in the training of a new generation of scientists in these four basic disciplines. During the next five years, the CBI Program is positioned to be a major contributor to the new interdisciplinary Life Sciences Initiative at the University of Michigan. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM008597-10
Application #
6895011
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Rogers, Michael E
Project Start
1996-07-01
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
10
Fiscal Year
2005
Total Cost
$242,909
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Taylor, Erin L; Kesavan, Preethi M; Wolfe, Abigail E et al. (2018) Distinguishing Specific and Nonspecific Complexes of Alkyladenine DNA Glycosylase. Biochemistry 57:4440-4454
Tebo, Alison G; Pinter, Tyler B J; García-Serres, Ricardo et al. (2018) Development of a Rubredoxin-Type Center Embedded in a de Dovo-Designed Three-Helix Bundle. Biochemistry 57:2308-2316
Haynes, Sarah E; Majmudar, Jaimeen D; Martin, Brent R (2018) DIA-SIFT: A Precursor and Product Ion Filter for Accurate Stable Isotope Data-Independent Acquisition Proteomics. Anal Chem 90:8722-8726
Kuo, Yu-Hsuan; Konopko, Aaron M; Borotto, Nicholas B et al. (2017) Profiling Protein S-Sulfination with Maleimide-Linked Probes. Chembiochem 18:2028-2032
Haynes, Sarah E; Polasky, Daniel A; Dixit, Sugyan M et al. (2017) Variable-Velocity Traveling-Wave Ion Mobility Separation Enhancing Peak Capacity for Data-Independent Acquisition Proteomics. Anal Chem 89:5669-5672
Waldschmidt, Helen V; Homan, Kristoff T; Cato, Marilyn C et al. (2017) Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem 60:3052-3069
Yim, Yun Young; McDonald, W Hayes; Hyde, Karren et al. (2017) Quantitative Multiple-Reaction Monitoring Proteomic Analysis of G? and G? Subunits in C57Bl6/J Brain Synaptosomes. Biochemistry 56:5405-5416
Bouley, Renee; Waldschmidt, Helen V; Cato, M Claire et al. (2017) Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol Pharmacol 92:707-717
Castañeda, Carol Ann; Wolfson, Noah A; Leng, Katherine R et al. (2017) HDAC8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared with peptides. J Biol Chem 292:21568-21577
Rogawski, David S; Vitanza, Nicholas A; Gauthier, Angela C et al. (2017) Integrating RNA sequencing into neuro-oncology practice. Transl Res 189:93-104

Showing the most recent 10 out of 89 publications