The UCSC graduate training program in Molecular, Cellular, and Developmental Biology provides intensive training in the skills necessary for outstanding research in modern biology. First year trainees undertake coursework emphasizing critical evaluation of scientific models and experimental results, and they also participate in three ten-week laboratory rotations. Second-year students take an oral qualifying exam, and advanced students participate in a variety of seminars, advanced special topics courses, and research group meetings designed to provide continuing learning opportunities. The goal of the training program is to produce graduates who have a strong foundation in the specific area of their thesis research, as well as broad training and knowledge in molecular, cellular, and developmental biology. The program is administered by Advising and Admissions Committees according to policy guidelines stated in our Graduate Handbook and Faculty Guidelines. The training program is composed of 19 members of the Department of IVICD Biology, and 9 affiliated faculty from the Departments of Biomolecular Engineering, Chemistry and Biochemistry, and Microbiology and Environmental Toxicology. The majority of the faculty members are housed in the Sinsheimer Laboratories, with other faculty located in the Physical Sciences Building, which is adjacent to Sinsheimer Labs. The MCD training program provides an interactive and collaborative research environment for graduate training. Research in the training program utilizes a wide variety of approaches and model organisms, and is organized as interdisciplinary clusters of faculty with shared interests, thereby creating critical masses of researchers that foster mutual support and scientific interaction. During the first 10 years of NIH training support we have recruited and trained outstanding students who would be amongst the best students in any training program. We are requesting a total of 8 predoctoral trainee positions in this renewal, which will continue to be awarded to our best students. Relevance: Students in the MCD Biology training program have extensive opportunities to study topics related to human health. Many training faculty work on systems that are directly relevant to human health, including stem cell biology, malaria, cholera, cancer biology, host-pathogen interactions, neurodegenerative diseases, and the responses of neurons to stroke and other damage. Other faculty carry out basic research that provides the foundation for understanding topics relevant to human health, including research focused on cell division, signaling, meiosis, chromatin remodeling, cell differentiation, and neurobiology.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008646-14
Application #
8294996
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
1999-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
14
Fiscal Year
2012
Total Cost
$204,909
Indirect Cost
$12,735
Name
University of California Santa Cruz
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
125084723
City
Santa Cruz
State
CA
Country
United States
Zip Code
95064
Howard, Jonathan M; Lin, Hai; Wallace, Andrew J et al. (2018) HNRNPA1 promotes recognition of splice site decoys by U2AF2 in vivo. Genome Res 28:689-698
Cuoco, Joshua A; Esposito, Anthony W; Moriarty, Shannon et al. (2018) Malformation of the Posterior Cerebellar Vermis Is a Common Neuroanatomical Phenotype of Genetically Engineered Mice on the C57BL/6 Background. Cerebellum 17:173-190
Warecki, Brandt; Sullivan, William (2018) Micronuclei Formation Is Prevented by Aurora B-Mediated Exclusion of HP1a from Late-Segregating Chromatin in Drosophila. Genetics 210:171-187
Schwiesow, Leah; Mettert, Erin; Wei, Yahan et al. (2018) Control of hmu Heme Uptake Genes in Yersinia pseudotuberculosis in Response to Iron Sources. Front Cell Infect Microbiol 8:47
Elling, Roland; Robinson, Elektra K; Shapleigh, Barbara et al. (2018) Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2. Cell Rep 25:1511-1524.e6
Bohr, Tisha; Nelson, Christian R; Giacopazzi, Stefani et al. (2018) Shugoshin Is Essential for Meiotic Prophase Checkpoints in C. elegans. Curr Biol 28:3199-3211.e3
Bogdanoff, Walter A; Perez, Edmundo I; López, Tomás et al. (2018) Structural Basis for Escape of Human Astrovirus from Antibody Neutralization: Broad Implications for Rational Vaccine Design. J Virol 92:
MacRae, Andrew J; Mayerle, Megan; Hrabeta-Robinson, Eva et al. (2018) Prp8 positioning of U5 snRNA is linked to 5' splice site recognition. RNA 24:769-777
Kessenbrock, Kai; Smith, Prestina; Steenbeek, Sander Christiaan et al. (2017) Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling. Proc Natl Acad Sci U S A 114:3121-3126
Peterson, Misty R; Hamdani, Omar; Kamakaka, Rohinton T (2017) Methods to Study the Atypical Roles of DNA Repair and SMC Proteins in Gene Silencing. Methods Mol Biol 1515:151-176

Showing the most recent 10 out of 88 publications