The UCSD Genetics Training Program (GTP) is designed to provide advanced training in Genetics and Genomics to predoctoral students beginning in their second graduate year. While several degree-granting umbrella programs at UCSD include genetics or genomics research, GTP is uniquely the point of integration across programs and builds both lateral and vertical cohorts of PhD students interested in the history, practice and future applications of Genetics and Genomics in life and health sciences. Mentor laboratories encompass a broad range of basic science and clinical/translation research and span a range of organisms?including microbial, plant, experimental animal, and human subjects?but share a focus on genetic, epigenetic and genomic mechanisms and approaches. Students who have committed to thesis research in one of these laboratories enter the GTP and may be selected for support by this training grant. The GTP curriculum cuts across traditional graduate programs in participating schools, divisions and departments. GTP students take graduate core courses in Genetics and Quantitative Methods and participate in a weekly journal club during graduate years 2-4. The journal club includes rotating topics in contemporary genetics or classic, landmark papers relevant to the intellectual development of the field. GTP students select quarterly topics in consultation with participating faculty. Journal club papers and discussion are used to assess methods and logic, experimental design, data analysis, and responsible conduct of research in additional to the quarterly research topics around which they are selected. A program-wide annual retreat, organized by year 5 students and a standing faculty committee, includes invited outside keynote speakers, research presentations by program faculty and students. GTP has more than 30-40 students training in any given year, for whom we are requesting 16 training grant slots.

Public Health Relevance

The UCSD Genetics Training Program rigorously prepares an exceptional pool of students for professional careers in basic and applied research in life and health sciences. Our graduates succeed in academic institutions, non-profit research institutions, biotechnology and drug research companies, and business firms that promote the development of health sciences companies. The overwhelming majority of our graduates remain in scientific careers that aim to promote and improve human health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008666-22
Application #
9969509
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Bender, Michael T
Project Start
1998-07-01
Project End
2022-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
22
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California, San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Hsu, Cynthia L; Lee, Elian X; Gordon, Kara L et al. (2018) MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. Nat Commun 9:942
Cowell, Annie N; Istvan, Eva S; Lukens, Amanda K et al. (2018) Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science 359:191-199
Wheeler, Emily C; Van Nostrand, Eric L; Yeo, Gene W (2018) Advances and challenges in the detection of transcriptome-wide protein-RNA interactions. Wiley Interdiscip Rev RNA 9:
Buckley, Alexandra R; Ideker, Trey; Carter, Hannah et al. (2018) Exome-wide analysis of bi-allelic alterations identifies a Lynch phenotype in The Cancer Genome Atlas. Genome Med 10:69
Veevers, Jennifer; Farah, Elie N; Corselli, Mirko et al. (2018) Cell-Surface Marker Signature for Enrichment of Ventricular Cardiomyocytes Derived from Human Embryonic Stem Cells. Stem Cell Reports 11:828-841
Lindsay, Scott A; Lin, Samuel J H; Wasserman, Steven A (2018) Short-Form Bomanins Mediate Humoral Immunity in Drosophila. J Innate Immun 10:306-314
Brandler, William M; Antaki, Danny; Gujral, Madhusudan et al. (2018) Paternally inherited cis-regulatory structural variants are associated with autism. Science 360:327-331
Wortham, Matthew; Benthuysen, Jacqueline R; Wallace, Martina et al. (2018) Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic ? Cell Function. Cell Rep 25:2904-2918.e8
Solomon, Terry; Lapek Jr, John D; Jensen, Søren Beck et al. (2018) Identification of Common and Rare Genetic Variation Associated With Plasma Protein Levels Using Whole-Exome Sequencing and Mass Spectrometry. Circ Genom Precis Med 11:e002170
Ghosh, Shereen G; Becker, Kerstin; Huang, He et al. (2018) Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. Am J Hum Genet 103:431-439

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