We are requesting continued funding of the Medical Sciences Training Program (MSTP) at the University of Wisconsin-Madison. The MSTP has made significant progress in its mission to provide outstanding, integrated training to physician-scientists. Core philosophies that have shaped the Program are (1) the rigor and caliber of both the M.D. and the Ph.D. training should be equivalent to those of single degree candidates;(2) students learn from one another;and (3) graduates, albeit to variable degrees, will be engaged in translational research. Three physician-scientists, each of whom is active in research, graduate training, and clinical activities, direct the MSTP. A student organization works closely with the directors. Directors also are advised by the MSTP Steering Committee, which includes faculty from the major Colleges and Schools of the University and insures that the MSTP exploits the breadth of training opportunities available to students at UW-Madison. The usual student does the preclinical phase of Medical School training while Becoming acquainted with research methodologies in a four-semester seminar/journal club course and participating in research rotations. Research mentors and graduate programs are chosen in the second year. A clinical bridging curriculum facilitates the transitions between graduate and medical work and also introduces students to clinical research. The major clinical courses of Medical School are done after completion of the Ph.D. thesis. The majority of student theses are in areas that require strong training in the traditional biological and chemical sciences, but a significant number of students are doing research on population-based problems and in engineering and in regenerative medicine. The regenerative medicine projects utilize mouse and human (WA01 and WA09) embryonic stem cells. Students produce substantial theses that result in important publications. Activities that foster program cohesiveness include a weekly seminar, yearly retreat, yearly symposium, and regular social gatherings. To have an interactive and dynamic group of students, we are aiming for a class size of ten students for an overall program size of 70- 80 students. Our long-term goal is to train a diverse group of physician-scientists who will have major impact on biomedical research and the practice of clinical medicine, and hence, will be future leaders in Academic Medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008692-12
Application #
7655430
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Shapiro, Bert I
Project Start
1998-07-01
Project End
2011-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
12
Fiscal Year
2009
Total Cost
$412,570
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Barkal, Amira A; Weiskopf, Kipp; Kao, Kevin S et al. (2018) Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy. Nat Immunol 19:76-84
Theisen, Erin; McDougal, Courtney E; Nakanishi, Masako et al. (2018) Cyclooxygenase-1 and -2 Play Contrasting Roles in Listeria-Stimulated Immunity. J Immunol 200:3729-3738
Barker, A K; Van Galen, A; Sethi, A K et al. (2018) Tobacco use as a screener for Clostridium difficile infection outcomes. J Hosp Infect 98:36-39
Lubin, Jonathan A; Zhang, Ray R; Kuo, John S (2018) Zika Virus has Oncolytic Activity Against Glioblastoma Stem Cells. Neurosurgery 82:E113-E114
Li, Yiping; Funk, Chadd; Dawkins, Demi et al. (2018) Leptomeningeal Enhancement Is Associated with Transient Neurologic Deficits after Flow Diversion of Intracranial Aneurysms. World Neurosurg 120:e94-e99
Liu, Shengchao; Alnammi, Moayad; Ericksen, Spencer S et al. (2018) Practical Model Selection for Prospective Virtual Screening. J Chem Inf Model :
Denu, Ryan A; Shabbir, Maria; Nihal, Minakshi et al. (2018) Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma. Mol Cancer Res 16:517-527
Rebernick, Ryan; Fahmy, Lauren; Glover, Christopher et al. (2018) DNA Area and NETosis Analysis (DANA): a High-Throughput Method to Quantify Neutrophil Extracellular Traps in Fluorescent Microscope Images. Biol Proced Online 20:7
Clark, Lindsay R; Koscik, Rebecca L; Allison, Samantha L et al. (2018) Hypertension and obesity moderate the relationship between ?-amyloid and cognitive decline in midlife. Alzheimers Dement :
Heffron, Anna S; Mohr, Emma L; Baker, David et al. (2018) Antibody responses to Zika virus proteins in pregnant and non-pregnant macaques. PLoS Negl Trop Dis 12:e0006903

Showing the most recent 10 out of 553 publications