This exciting pre-doctoral training program at the Chemistry-Biology Interface involves 31 training faculty from three departments at the University of Minnesota: Chemistry, Medicinal Chemistry, and Biochemistry, Molecular Biology and Biophysics (BMBB). The mission of the CBITG at the University of Minnesota is to provide a diverse cadre of students with the skills necessary to cross traditional boundaries and understand and conduct scientific research at the interface of chemistry and biology. This mission will be accomplished by achieving the following objectives: (i) Provide students with an interdisciplinary training experience at the interface of chemistry and biology through a combination of coursework involving classes from at least two departments and by a cross-training experience involving a coadvisor and a research experience of three months in the coadvisor's laboratory. (ii) Expose students to cutting-edge science at the interface of chemistry and biology through seminars focused on this type of interfacial science (Chemical Biology Colloquium) and by allowing them to organize their own symposium focused on the chemical biology interface. (iii) Enhance the communication skills of trainees by providing them with multiple opportunities to present their research including a presentation at a national or international conference. (iv) Educate students about the range of career opportunities available for scientists with training in this area. (v) Stimulate interest in our training program through te use of interviews with trainees, trainers and prominent scientists working at the chemistry/biology interface. (vi) Increase the diversity of scientists carrying out research at the chemistry and biology interface in our program through a combination of different outreach activities. Trainees will be involved in research themes that include: Biocatalysis and Biomolecular Design (Distefano, Kazlauskas, Lipscomb, Ohlendorf, Schmidt-Dannert, Seelig Wackett, Wagner, Wilmot), Therapeutic Agents (Aldrich, Amin, Bernlohr, Distefano, Georg, Harki, Haskell-Luevano, Hoye, Mansky, Tretyakova, Wagner, Xing), Chemistry of Disease (Aldrich, Arriaga, Bernlohr, Distefano, Harki, Haskell-Luevano, Mansky, Murphy, Pomerantz, Tretyakova, Wagner, Xing), Metallobiochemistry (Amin, Lipscomb, Murphy, Ohlendorf, Pierre, Que, Wackett, Wilmot), and Bioanalytical/Biophysical (Arriaga, Bowser, Griffin, Haynes, Pierre, Pomerantz, Tretyakova, Thomas, Veglia). The research groups of the training faculty are all well supported and well equipped. This highly successful training program has been ongoing for 14 years. In this period, support is requested for 8 trainees each year of the program, each to be supported for a two-year period.

Public Health Relevance

The trainers and their trainees collectively carry out research on fundamental questions related to current important problems in public health. These include understanding how cancers are initiated in the cell, how obesity and diabetes develop and how a muscle works, designing and developing new drugs and probes for cancer, HIV and Alzheimer's disease, and understanding how chemicals are transformed and broken down in the environment.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Program Officer
Fabian, Miles
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Minnesota Twin Cities
Schools of Arts and Sciences
United States
Zip Code
Gee, Clifford T; Arntson, Keith E; Koleski, Edward J et al. (2018) Dual Labeling of the CBP/p300 KIX Domain for 19 F?NMR Leads to Identification of a New Small-Molecule Binding Site. Chembiochem 19:963-969
Martin, Peter D; James, Zachary M; Thomas, David D (2018) Effect of Phosphorylation on Interactions between Transmembrane Domains of SERCA and Phospholamban. Biophys J 114:2573-2583
Diaz-Rodriguez, Veronica; Hsu, Erh-Ting; Ganusova, Elena et al. (2018) a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity. Bioconjug Chem 29:316-323
Divakaran, Anand; Talluri, Siva K; Ayoub, Alex M et al. (2018) Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. J Med Chem 61:9316-9334
Komor, Anna J; Jasniewski, Andrew J; Que, Lawrence et al. (2018) Diiron monooxygenases in natural product biosynthesis. Nat Prod Rep 35:646-659
Muratore, Katherine A; Najt, Charles P; Livezey, Nicholas M et al. (2018) Sizing lipid droplets from adult and geriatric mouse liver tissue via nanoparticle tracking analysis. Anal Bioanal Chem 410:3629-3638
Olson, Erik D; Musier-Forsyth, Karin (2018) Retroviral Gag protein-RNA interactions: Implications for specific genomic RNA packaging and virion assembly. Semin Cell Dev Biol :
Buonomo, Joseph A; Eiden, Carter G; Aldrich, Courtney C (2018) Scalable Synthesis of Hydrido-Disiloxanes from Silanes: A One-Pot Preparation of 1,3-Diphenyldisiloxane from Phenylsilane. Synthesis (Stuttg) 50:278-281
Jensen, Matthew R; Goblirsch, Brandon R; Esler, Morgan A et al. (2018) The role of OleA His285 in orchestration of long-chain acyl-coenzyme A substrates. FEBS Lett 592:987-998
Kotandeniya, D; Seiler, C L; Fernandez, J et al. (2018) Can 5-methylcytosine analogues with extended alkyl side chains guide DNA methylation? Chem Commun (Camb) 54:1061-1064

Showing the most recent 10 out of 126 publications