This Ruth Kirschstein NRSA training Program in its 14th year proposes to take primarily surgeons and other critical care medicine physicians during the second or third year of their general residency programs, and expose them to two, three and even four years of mentored research in inflammation biology with highly productive basic science mentors focused on inflammation-related topics. The overall research program will focus on mastery of molecular biology, functional genomics and gene regulation, as it applies broadly to inflammation research. Three training positions are requested. This program will take advantage of the unique strengths of the College of Medicine in the expanding field of functional genomics and molecular biology, as well as the collaborations between basic scientists and clinicians committed to the training of future clinical academicians. Select trainees will have the opportunity to complete a Ph.D. program in the Graduate School in three to four years. The interface between molecular biology and inflammation research will be targeted to trauma, sepsis syndromes, ischemia/reperfusion injury, vascular injury, delayed wound healing and the burn wound. The faculty will be drawn from funded basic scientists in the Surgery, Medicine, Pathology, Periodontology, and Molecular Genetics and Microbiology Departments, who will serve as research mentors to the trainees. Clinical mentors from the Surgery, Medicine and Pathology Departments will interact with the trainees and the research faculty to assure that the trainees are being exposed to clinically-important issues in inflammation research. Overall direction of the program will rest with the Program Director and the Executive Committee. Candidates for the fellowship will be recruited nationally and from the University of Florida College of Medicine. Successful applicants with the Executive Committee will identify a research and clinical mentor who will help formulate a formal training program and periodic review of the trainee's progress. The bulk of the training program will be in the laboratory of an experienced research mentor, but trainees will also be required to fulfill basic course work in research ethics and statistical methods, and will be encouraged to obtain supplemental didactic training in molecular biology. Furthermore, trainees are expected to participate in basic science seminars in the Emerging Pathogens Institute and Genetics Institute, and in their own basic science departments, as well as laboratory research meetings. They will also be expected to attend clinical seminars, including Surgery and Critical Care Medicine Grand Rounds and the Department of Surgery Academic Research Conference. It is anticipated that successful graduates will possess sufficient research skills to compete for transitional funding in inflammation research.
Society recognizes the critical role that clinician-scientists play in translational biology and the application of new technologies to the clinic. We propose that a 2-4 year immersion by a young interested clinician in the laboratory of a successful basic scientist with expertise in molecular biology will provide a sound foundation for a career as a physician/scientist involved in translational research in inflammation biology, relevant to trauma, sepsis and burns. The successful trainee will have expertise in functional genomics, molecular genetics and molecular biology to help translate the current genomic revolution to improved clinical practice.
| Loftus, Tyler J; Efron, Philip A; Bala, Trina M et al. (2018) Hypertonic saline resuscitation after emergent laparotomy and temporary abdominal closure. J Trauma Acute Care Surg 84:350-357 |
| Stortz, Julie A; Murphy, Tyler J; Raymond, Steven L et al. (2018) Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis. Shock 49:249-258 |
| Loftus, Tyler J; Jordan, Janeen R (2018) Response to Er and Tez: the use of artificial neural networks in medical prognostication. J Surg Res 222:226 |
| Loftus, Tyler J; Rosenthal, Martin D; Croft, Chasen A et al. (2018) The effects of beta blockade and clonidine on persistent injury-associated anemia. J Surg Res 230:175-180 |
| Horiguchi, Hiroyuki; Loftus, Tyler J; Hawkins, Russell B et al. (2018) Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy. Front Immunol 9:595 |
| Delitto, Daniel; George Jr, Thomas J; Loftus, Tyler J et al. (2018) Prognostic Value of Clinical vs Pathologic Stage in Rectal Cancer Patients Receiving Neoadjuvant Therapy. J Natl Cancer Inst 110:460-466 |
| Loftus, Tyler J; Brakenridge, Scott C; Croft, Chasen A et al. (2018) Successful nonoperative management of uncomplicated appendicitis: predictors and outcomes. J Surg Res 222:212-218.e2 |
| Mira, Juan C; Nacionales, Dina C; Loftus, Tyler J et al. (2018) Mouse Injury Model of Polytrauma and Shock. Methods Mol Biol 1717:1-15 |
| Loftus, Tyler J; Brakenridge, Scott C; Murphy, Travis W et al. (2018) Anemia and blood transfusion in elderly trauma patients. J Surg Res 229:288-293 |
| Loftus, Tyler J; Rosenthal, Martin D; Croft, Chasen A et al. (2018) Effect of Time to Operation on Value of Care in Acute Care Surgery. World J Surg 42:2356-2363 |
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