Abstract

This Biotechnology Training Program, """"""""Leadership in Pharmaceutical Biotechnology Training Program,"""""""" is currently in its fifth year of NIH funding. During its initial period, the training program has attracted a pool of talented trainees from Chemical and Biological Engineering, Pharmaceutical Sciences, and Chemistry and Biochemistry. Under the guidance of a group of dedicated training faculty and in collaboration with a pool of industrial scientists who served as mentors and offered internships, these trainees have received a broad, interdisciplinary training that features not only science and engineering fundamentals, but also strong training in ethical conduct of research, a focus on entrepreneurship and intellectual property, and coaching in leadership. ? ? In this renewal application, we describe how trainees from diverse backgrounds in life sciences and engineering will receive state-of-the art training in a cross-disciplinary, team-based setting that will allow them to become the future leaders of the pharmaceutical biotechnology industry. ? ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008732-08
Application #
7475770
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Jones, Warren
Project Start
2001-07-01
Project End
2011-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
8
Fiscal Year
2008
Total Cost
$221,267
Indirect Cost

  Institution

Name
University of Colorado at Boulder
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
007431505
City
Boulder
State
CO
Country
United States
Zip Code
80309

  Publications

Carter, Kyle P; Carpenter, Margaret C; Fiedler, Brett et al. (2017) Critical Comparison of FRET-Sensor Functionality in the Cytosol and Endoplasmic Reticulum and Implications for Quantification of Ions. Anal Chem 89:9601-9608
Fiedler, Brett L; Van Buskirk, Steven; Carter, Kyle P et al. (2017) Droplet Microfluidic Flow Cytometer For Sorting On Transient Cellular Responses Of Genetically-Encoded Sensors. Anal Chem 89:711-719
Li, Jing; Yakushi, Tanya; Parlati, Francesco et al. (2017) Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol 13:486-493
Lauinger, Linda; Li, Jing; Shostak, Anton et al. (2017) Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol 13:709-714
Young, Alexandra M; Minson, Michael; McQuate, Sarah E et al. (2017) Optimized Fluorescence Complementation Platform for Visualizing Salmonella Effector Proteins Reveals Distinctly Different Intracellular Niches in Different Cell Types. ACS Infect Dis 3:575-584
Erickson, Keesha E; Otoupal, Peter B; Chatterjee, Anushree (2017) Transcriptome-Level Signatures in Gene Expression and Gene Expression Variability during Bacterial Adaptive Evolution. mSphere 2:
Otoupal, Peter B; Erickson, Keesha E; Escalas-Bordoy, Antoni et al. (2017) CRISPR Perturbation of Gene Expression Alters Bacterial Fitness under Stress and Reveals Underlying Epistatic Constraints. ACS Synth Biol 6:94-107
Nordwald, Erik M; Plaks, Joseph G; Snell, Jared R et al. (2015) Crystallographic Investigation of Imidazolium Ionic Liquid Effects on Enzyme Structure. Chembiochem 16:2456-9
Plaks, Joseph G; Falatach, Rebecca; Kastantin, Mark et al. (2015) Multisite clickable modification of proteins using lipoic acid ligase. Bioconjug Chem 26:1104-12
MacConaghy, Kelsey I; Chadly, Duncan M; Stoykovich, Mark P et al. (2015) Label-free detection of missense mutations and methylation differences in the p53 gene using optically diffracting hydrogels. Analyst 140:6354-62

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