This training grant proposal on the """"""""The cellular and molecular foundations of biomedical sciences"""""""" is a renewal of a successful program started eleven years ago. It seeks to train graduate students in the broad fundamentals of biomedical sciences to provide them with the tools to understand important problems in modern biology and health. This is accomplished initially through Core course modules in the first year covering Genetics, Molecular Biology, Structural Biology, Biophysics, Cell Biology and Genomics and Systems Biology. Students follow this with electives in specific fields of their interest. The program is based in the Department of Biological Sciences, but has been expanded to include established faculty from Columbia's College of Physicians and Surgeons as well as faculty in the Department of Chemistry. Students undertake rotations in up to three laboratories and can do their thesis work with any of the 55 faculty in the program, roughly half of which are on the Medical School and Main campuses, respectively. This has provided expanded opportunities for training of the students in outstanding laboratories and has fostered collaboration between faculty and students at Columbia's Medical School and main campuses. The faculty work in a broad range of fields including structural biology, molecular biology, microbiology, genetics, bioinformatics and systems biology, developmental biology and neurobiology. Experimental systems are also broad including bacteria, yeast, drosophila, C. elegans, frogs and mice. Human tissue culture systems are also utilized and most systems consider problems relevant to human health and physiology. Ten graduate student traineeships are requested per year to support five students for two years each, usually in their third and fourth years. This will fund 14.5% of our current training grant eligible student pool of 69. The best students in our program will be chosen to be funded by this grant. This will be determined by their performance in the Core and other courses, recommendations from their rotation and thesis sponsors, and a short research proposal reviewed by the grant's steering committee. The qualifications of the faculty and the research facilities at Columbia are outstanding and provide a superb training environment for the students. The record of outstanding publications by the students also demonstrates the success of this program.
The training of the next generation of biomedical scientists is essential to continued excellence of research in the U.S. and advances in understanding, controlling and curing human disease. Laboratories in the program address specific basic problems in biomedical sciences, many with direct applications to human disease.
|Lin, Yu-Cheng; Cornell, William Cole; Jo, Jeanyoung et al. (2018) The Pseudomonas aeruginosa Complement of Lactate Dehydrogenases Enables Use of d- and l-Lactate and Metabolic Cross-Feeding. MBio 9:|
|Yurko, Nathan M; Manley, James L (2018) The RNA polymerase II CTD ""orphan"" residues: Emerging insights into the functions of Tyr-1, Thr-4, and Ser-7. Transcription 9:30-40|
|Tomljanovic, Zeljko; Patel, Mitesh; Shin, William et al. (2018) ZCCHC17 is a master regulator of synaptic gene expression in Alzheimer's disease. Bioinformatics 34:367-371|
|Rajbhandari, Presha; Lopez, Gonzalo; Capdevila, Claudia et al. (2018) Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma. Cancer Discov 8:582-599|
|Burn, Sally F; Washkowitz, Andrew J; Gavrilov, Svetlana et al. (2018) Postimplantation Mga expression and embryonic lethality of two gene-trap alleles. Gene Expr Patterns 27:31-35|
|Smith, Michael J; Bryant, Eric E; Rothstein, Rodney (2018) Increased chromosomal mobility after DNA damage is controlled by interactions between the recombination machinery and the checkpoint. Genes Dev 32:1242-1251|
|Conlon, Erin G; Fagegaltier, Delphine; Agius, Phaedra et al. (2018) Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism. Elife 7:|
|Liu, Xiaochuan; Hoque, Mainul; Larochelle, Marc et al. (2017) Comparative analysis of alternative polyadenylation in S. cerevisiae and S. pombe. Genome Res 27:1685-1695|
|Billon, Pierre; Bryant, Eric E; Joseph, Sarah A et al. (2017) CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons. Mol Cell 67:1068-1079.e4|
|Li, Minghui; Zhang, Wei K; Benvin, Nicole M et al. (2017) Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel. Nat Struct Mol Biol 24:205-213|
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