This is a competitive renewal application for the post-doctoral multidisciplinary basic science Trauma and Inflammation Research Training Program at the Department of Surgery, The Alpert Medical School of Brown University. The Program's goal is to identify, recruit, and train the next generation of Trauma and Inflammation Scientists with particular emphasis on retaining MDs in academic careers. Formal training in research involves the acquisition of the technical, intellectual, philosophical and ethical habits and abilities of the scientist. Development of these traits in the trainees is the most important goal of the Program. Faculty from the Departments of Surgery (Acute Care, Burns, Cardiothoracic, Trauma); Medicine (Infectious Diseases, Pulmonology); Orthopedics; Molecular Microbiology and Immunology; Molecular Biology, Cell Biology and Biochemistry; Molecular Pharmacology, Physiology, and Biotechnology; and Pathology at Brown University, and their respective laboratories, afford trainees ideal opportunities to select areas for research. The Level 1 Trauma and Burn Centers at Rhode Island Hospital provide clinical correlates for basic research. The Program is led by a Director who is advised and assisted by an Executive Committee in the selection, guidance and evaluation of trainees. A Co-Director assists the Director in the day-to-day running of the program and stands-in in his absence. An Extramural Advisors Panel assures the excellence of the Training Program. Two trainees per year are selected nationally, among residents in any branch of surgery or medicine and recently graduated PhDs. Major emphasis is placed on recruiting candidates from under-represented minorities, the disabled, and veterans. The Training Program lasts two years. The curriculum includes required courses in Biostatistics, Responsible Conduct of Research, Rigor and Reproducibility, and Scientific Writing, as well as elective courses tailored to the specific needs of the trainees. A faculty mentor and an Advisory Group (modeled after a PhD thesis committee and including an experienced trauma care clinician) provide direction, support and supervision to the trainee, as well as assuring the clinical relevance of the research project. The Advisory Group assists the trainee and his/her mentor in designing and implementing an Individual Development Plan (IDP) to guide the trainee?s scientific development. Trainees will have no mandatory clinical responsibilities during the training period. This comprehensive program provides the trainee with the technical and intellectual tools necessary to pursue an academic career in research areas related to trauma and inflammation.
Trauma continues to be a leading cause of death and disability in the USA. The Program aims to train surgical residents or recently graduated PhDs as the next generation of Trauma Scientists, capable of bringing advances in the understanding of the underlying mechanisms of ?trauma disease? and inflammation to the bedside and improve the outcome of trauma victims.
|Potz, Brittany A; Scrimgeour, Laura A; Pavlov, Vasile I et al. (2018) Extracellular Vesicle Injection Improves Myocardial Function and Increases Angiogenesis in a Swine Model of Chronic Ischemia. J Am Heart Assoc 7:|
|Chun, Tristen T; Chung, Chun-Shiang; Fallon, Eleanor A et al. (2018) Group 2 Innate Lymphoid Cells (ILC2s) Are Key Mediators of the Inflammatory Response in Polymicrobial Sepsis. Am J Pathol 188:2097-2108|
|Potz, Brittany A; Scrimgeour, Laura A; Sabe, Sharif A et al. (2018) Glycogen synthase kinase 3? inhibition reduces mitochondrial oxidative stress in chronic myocardial ischemia. J Thorac Cardiovasc Surg 155:2492-2503|
|Dickinson, Catherine M; LeBlanc, Brian W; Edhi, Muhammad M et al. (2018) Leukadherin-1 ameliorates endothelial barrier damage mediated by neutrophils from critically ill patients. J Intensive Care 6:19|
|Sabe, Sharif A; Feng, Jun; Liu, Yuhong et al. (2018) Decreased contractile response of peripheral arterioles to serotonin after CPB in patients with diabetes. Surgery 164:288-293|
|Potz, Brittany A; Parulkar, Anshul B; Abid, Ruhul M et al. (2017) Novel molecular targets for coronary angiogenesis and ischemic heart disease. Coron Artery Dis 28:605-613|
|Potz, Brittany A; Sabe, Ashraf A; Elmadhun, Nassrene Y et al. (2017) Calpain inhibition modulates glycogen synthase kinase 3? pathways in ischemic myocardium: A proteomic and mechanistic analysis. J Thorac Cardiovasc Surg 153:342-357|
|Potz, Brittany A; Sabe, Ashraf A; Elmadhun, Nassrene Y et al. (2017) Calpain inhibition decreases inflammatory protein expression in vessel walls in a model of chronic myocardial ischemia. Surgery 161:1394-1404|
|Potz, Brittany A; Scrimgeour, Laura A; Feng, Jun et al. (2017) Diabetes and Cardioplegia. J Nat Sci 3:|
|Scrimgeour, Laura A; Potz, Brittany A; Elmadhun, Nassrene Y et al. (2017) Alcohol attenuates myocardial ischemic injury. Surgery 162:680-687|
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