This proposal requests funds for a Chemistry/Biology Interface Training Program at Vanderbilt University. Sixteen faculty preceptors from six departments in the College of Arts and Science and in the School of Medicine will serve as mentors for the Program. Significant biological training will be provided to students receiving in-depth training in synthetic and mechanistic chemistry and significant training in synthetic and mechanistic chemistry will be given to students being trained in-depth in the biological sciences. Students will be well-grounded in a core discipline and sufficiently well-trained in complementary fields to allow them to work effectively in a multi-disciplinary team. Support for five Trainees is proposed in the first year with ten Trainees requested in subsequent years at the steady-state level. Vanderbilt University has provided financial support for a pilot training program during the past year in which two Trainees were recruited to the Program and a Seminar Series in Science at the Chemistry-Biology Interface was offered. Trainees will obtain Ph.D. degrees working with Preceptors in the Departments of Biochemistry (5 preceptors) Biological Science (2 preceptors), Chemistry (6 preceptors), Molecular Physiology and Biophysics (1 preceptor), Immunology (1 preceptor), and Pharmacology (1 preceptor). All trainees will complete a core curriculum consisting of courses in Bio-organic Chemistry and Enzyme Mechanisms and Function. Trainees will also participate in a seminar series in Chemical Biology that will serve as a focal point for the program. Student Trainees and Preceptors will present research at these seminars in order to provide an interdisciplinary environment and cross-fertilization of ideas.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM065086-03
Application #
6764110
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Rogers, Michael E
Project Start
2002-07-01
Project End
2007-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
3
Fiscal Year
2004
Total Cost
$306,311
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Biochemistry
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Choby, Jacob E; Buechi, Hanna B; Farrand, Allison J et al. (2018) Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus. MBio 9:
Morgan, Amanda J; Kingsley, Philip J; Mitchener, Michelle M et al. (2018) Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain. ACS Chem Neurosci 9:1552-1559
Cassat, James E; Moore, Jessica L; Wilson, Kevin J et al. (2018) Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions. Sci Transl Med 10:
Kovtun, Oleg; Tomlinson, Ian D; Bailey, Danielle M et al. (2018) Single Quantum Dot Tracking Illuminates Neuroscience at the Nanoscale. Chem Phys Lett 706:741-752
Chambers, Schuyler A; DeSousa, Jenna M; Huseman, Eric D et al. (2018) The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production. ACS Chem Neurosci 9:2307-2330
Dutter, Brendan F; Ender, Anna; Sulikowski, Gary A et al. (2018) Rhodol-based thallium sensors for cellular imaging of potassium channel activity. Org Biomol Chem 16:5575-5579
Kozek, Krystian A; Du, Yu; Sharma, Swagat et al. (2018) Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels. ACS Chem Neurosci :
Ackerman, Dorothy L; Craft, Kelly M; Doster, Ryan S et al. (2018) Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii. ACS Infect Dis 4:315-324
Reid, Kemar R; McBride, James R; Freymeyer, Nathaniel J et al. (2018) Chemical Structure, Ensemble and Single-Particle Spectroscopy of Thick-Shell InP-ZnSe Quantum Dots. Nano Lett 18:709-716
Earl, David C; Ferrell Jr, P Brent; Leelatian, Nalin et al. (2018) Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics. Nat Commun 9:39

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