This proposal requests continuing support for a Vanderbilt Chemistry-Biology Interface (V-CBI) Training Program at Vanderbilt University. Thirty-six faculty preceptors from eight Ph.D. granting departments and programs in the Colleges of Arts and Sciences and Basic Sciences will serve as mentors for the Program. Signicant training and education in biology will be provided to students receiving in-depth training in synthetic/mechanistic and analytical chemistry and significant training and education in the chemistry will be provided to students receiving in-depth training in the biological sciences. Highlights of the training program include a common chemical biology 15 week course, elective courses for cross education, a course in experimental design and research reproducibility, student organized research and professional development seminars, a semnar series in chemical biology, an annual research symposium, participation in an annual career development conference and a unique experience in laboratory experimental design and technical training for application in an undergraduate research laboratory. Students will receive in-depth education and training in a core discipline and cross training in complementary fields to allow them to work effectively in multidisciplinary research environment. Support for ten trainees is requested. Trainees will obtain Ph.D. degrees working with preceptors in the Departments of Biochemistry (10 preceptors), Chemistry (10 preceptors), Cell and Developmental Biology (2 preceptors), Pathology and Microbiology (3 preceptor), Pharmacology (5 preceptors) and Radiology and Radiological Science (1 preceptor).

Public Health Relevance

The trainees participating in the CBI training program are engaged in a number of NIH-supported projects that employ techniques, understanding and tools of chemistry to study a variety of biomedical problems with relevance to the study of human biology, health and therapeutic agent development.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM065086-18
Application #
9968410
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Fabian, Miles
Project Start
2002-07-01
Project End
2023-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
18
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Biochemistry
Type
Schools of Medicine
DUNS #
965717143
City
Nashville
State
TN
Country
United States
Zip Code
37203
Craft, Kelly M; Townsend, Steven D (2018) The Human Milk Glycome as a Defense Against Infectious Diseases: Rationale, Challenges, and Opportunities. ACS Infect Dis 4:77-83
Choby, Jacob E; Grunenwald, Caroline M; Celis, Arianna I et al. (2018) Staphylococcus aureus HemX Modulates Glutamyl-tRNA Reductase Abundance To Regulate Heme Biosynthesis. MBio 9:
Choby, Jacob E; Buechi, Hanna B; Farrand, Allison J et al. (2018) Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus. MBio 9:
Morgan, Amanda J; Kingsley, Philip J; Mitchener, Michelle M et al. (2018) Detection of Cyclooxygenase-2-Derived Oxygenation Products of the Endogenous Cannabinoid 2-Arachidonoylglycerol in Mouse Brain. ACS Chem Neurosci 9:1552-1559
Cassat, James E; Moore, Jessica L; Wilson, Kevin J et al. (2018) Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions. Sci Transl Med 10:
Kovtun, Oleg; Tomlinson, Ian D; Bailey, Danielle M et al. (2018) Single Quantum Dot Tracking Illuminates Neuroscience at the Nanoscale. Chem Phys Lett 706:741-752
Chambers, Schuyler A; DeSousa, Jenna M; Huseman, Eric D et al. (2018) The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production. ACS Chem Neurosci 9:2307-2330
Dutter, Brendan F; Ender, Anna; Sulikowski, Gary A et al. (2018) Rhodol-based thallium sensors for cellular imaging of potassium channel activity. Org Biomol Chem 16:5575-5579
Kozek, Krystian A; Du, Yu; Sharma, Swagat et al. (2018) Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels. ACS Chem Neurosci :
Ackerman, Dorothy L; Craft, Kelly M; Doster, Ryan S et al. (2018) Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii. ACS Infect Dis 4:315-324

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