Physician scientists (MD-PhDs) are uniquely positioned to address many of the challenges at the forefront of modern medicine. During the first 14 years of support, the Mayo Clinic MSTP has dedicated itself to training talented and passionate students to be critical, productive physician scientists. Our mission is to prepare our students for academic careers in basic, translational and clinical research, focused on studying fundamental questions and translating basic discoveries into medical advances. The program philosophy is that the skills required for this type of academic career are best developed in a basic research setting. However, the unique quality of the physician scientist is the ability to integrate basic studies with translational and clinical research to ultimately advance the practice of medicine, and the Mayo Clinic MSTP strives continually to improve the integration of clinical and basic research training. First awarded an MSTP grant in 2003 and renewed twice, our MSTP has continued to develop and mature while maintaining aspects that were previously praised by reviewers. The main strengths of our MSTP are: ? An enthusiastic training faculty of 71 mentors who provide extensive opportunities for cutting-edge interdisciplinary training in basic, translational, and clinical research; ? Outstanding current trainees who are passionate about the study of fundamental biological processes of relevance to human disease; ? A highly competitive applicant pool; ? An autonomous admissions process that enables selection of students based on their prior research experiences and excitement for biomedical research; ? An effective recruitment and retention plan to enhance diversity, with three URM students who completed training during the past five years and 12 URM or students with disabilities currently in training; ? Integration of medical and graduate school curricula, which allows students to complete three required graduate courses and two laboratory rotations during MS1 and MS2; ? Programmatic features, including the MSTP Selectives, Weekly MSTP Conferences, MSTP Annual Retreat, MSTP Clinical Experiences Program and MSTP Clinical Re-Entry Course, as well as individualized development support that respond to specific needs of MD-PhD trainees; ? Strong institutional support for education, which enables us to fund our MD-PhD students throughout their medical and graduate training, providing exceptional flexibility in choosing thesis laboratories; ? Exceptional research resources that enhance our students' educational experiences; ? A dedicated, interactive, and supportive team consisting of the Director, Associate Directors, administrators and student leadership.

Public Health Relevance

The educational mission of the Mayo Clinic MSTP is to train future leaders in biomedical research and academic medicine. In addition to providing strong education in medicine and intensive training in scientific inquiry, we strive to (i) train our students to seek medical implications in even the most basic scientific discoveries; (ii) foster their innate curiosity so that they will be keen to take clinical questions back to the laboratory to look for new fundamental knowledge; and (iii) develop their leadership and collaborative skills so that they will be prepared to bridge basic and clinical research efforts as they pave the way for innovative solutions to medical problems. Mayo Clinic's exceptionally strong integration between basic science and clinical and translational research fosters the environment necessary to achieve our educational mission.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM065841-16
Application #
9489658
Study Section
NIGMS Initial Review Group (TWD)
Program Officer
Gindhart, Joseph G
Project Start
2003-07-01
Project End
2023-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
16
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Singh, Raman Deep; Hillestad, Matthew L; Livia, Christopher et al. (2018) M3RNA Drives Targeted Gene Delivery in Acute Myocardial Infarction. Tissue Eng Part A :
Wilton, Katelynn M; Matteson, Eric L; Crowson, Cynthia S (2018) Risk of Obstructive Sleep Apnea and Its Association with Cardiovascular and Noncardiac Vascular Risk in Patients with Rheumatoid Arthritis: A Population-based Study. J Rheumatol 45:45-52
Smestad, John; Erber, Luke; Chen, Yue et al. (2018) Chromatin Succinylation Correlates with Active Gene Expression and Is Perturbed by Defective TCA Cycle Metabolism. iScience 2:63-75
Cohen, Devon A; Lopez-Chiriboga, A Sebastian; Pittock, Sean J et al. (2018) Posttransplant autoimmune encephalitis. Neurol Neuroimmunol Neuroinflamm 5:e497
Wilton, Katelynn M; Billadeau, Daniel D (2018) VASP Regulates NK Cell Lytic Granule Convergence. J Immunol 201:2899-2909
Naylor, Ryan M; Wohl, Anton; Raghunathan, Aditya et al. (2018) Novel suprasellar location of desmoplastic infantile astrocytoma and ganglioglioma: a single institution's experience. J Neurosurg Pediatr 22:397-403
Jo, Hang Joon; McCairn, Kevin W; Gibson, William S et al. (2018) Global network modulation during thalamic stimulation for Tourette syndrome. Neuroimage Clin 18:502-509
Moyer, Ann M; de Andrade, Mariza; Faubion, Stephanie S et al. (2018) SLCO1B1 genetic variation and hormone therapy in menopausal women. Menopause 25:877-882
Li, Lei; Liu, Tongzheng; Li, Yunhui et al. (2018) The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistance through YAP1 stabilization. Oncogene 37:2422-2431
Paradise, Brooke D; Barham, Whitney; Fernandez-Zapico, Martín E (2018) Targeting Epigenetic Aberrations in Pancreatic Cancer, a New Path to Improve Patient Outcomes? Cancers (Basel) 10:

Showing the most recent 10 out of 112 publications