Support is requested to continue what has proven to be a highly successful program for the training of predoctoral students at the interface of chemistry and biology. Over the past fifteen years, this CBI training program has supported 66 graduate students, eight of which have subsequently received NSF, Keck Foundation, National Defense Science and Engineering Graduate (NDSEG) or American Cancer Society predoctoral fellowships. In addition, Yale has made a conscious effort to increase its representation in this interdisciplinary area through new hires and promotions at the junior and senior levels in the departments of Molecular, Cellular and Developmental Biology (MCDB), Chemistry, and Molecular Biophysics and Biochemistry (MB&B). Moreover, Yale University?s acquisition of the former Bayer Pharmaceuticals R&D site in neighboring West Haven allowed the launch a Chemical Biology Institute, which will ultimately house 9 additional faculty working at the chemistry/biology interface. Given this expansion of faculty, additional funds are requested to support a total of 12 CBI predoctoral trainees. All trainees admitted to the program have at least a Bachelor?s degree in a relevant field and enter via application to the Chemistry department or to the Yale Biological and Biomedical Sciences (BBS) program. Regardless of mode of entry all trainees share a common first year experience involving interdisciplinary course work, laboratory rotations, as well as close supervision and guidance from the Director of Graduate Students in conjunction with the Executive Committee. At the end of their first year, trainees chose a thesis advisor from among the 27 CBI trainers and begin intensive research with additional courses in their second year. Students are supported on this grant in years two and three of their doctoral training. All students teach for at least one year to aid in their training as teacher-scholars. Programs for increasing the number of minority trainees and for providing education in ethical issues related to research represent important parts of this training program. Special features of the training program include interdepartmental course work, including specially designed courses for the new trainees, a rigorous interdepartmental rotation schedule during which the trainee will experience science in three laboratories at Yale, a monthly in-house seminar program for discussion of recent results, Chemical Biology Fall Retreat and a highly successful annual Chemical Biology Symposium with a CBI Trainee Poster competition.
The Predoctoral Training Program at the Chemistry/Biology interface at Yale University supports the multi-disciplinary graduate education of the next generation of research scientists in chemical biology. Graduates from this program go on to research positions in universities, research institutes, and industry, where they contribute to finding medical solutions to genetic diseases, cancers, and other disorders that afflict humans.
| Baranovskiy, Andrey G; Duong, Vincent N; Babayeva, Nigar D et al. (2018) Activity and fidelity of human DNA polymerase ? depend on primer structure. J Biol Chem 293:6824-6843 |
| Jackson, Ruaidhrí; Kroehling, Lina; Khitun, Alexandra et al. (2018) The translation of non-canonical open reading frames controls mucosal immunity. Nature 564:434-438 |
| Sinclair, Julie K L; Walker, Allison S; Doerner, Amy E et al. (2018) Mechanism of Allosteric Coupling into and through the Plasma Membrane by EGFR. Cell Chem Biol 25:857-870.e7 |
| Schuppe, Alexander W; Huang, David; Chen, Yifeng et al. (2018) Total Synthesis of (-)-Xylogranatopyridine B via a Palladium-Catalyzed Oxidative Stannylation of Enones. J Am Chem Soc 140:2062-2066 |
| Chen, Yifeng; Huang, David; Zhao, Yizhou et al. (2017) Allyl-Palladium-Catalyzed Ketone Dehydrogenation Enables Telescoping with Enone ?,?-Vicinal Difunctionalization. Angew Chem Int Ed Engl 56:8258-8262 |
| Park, Hyun Bong; Perez, Corey E; Barber, Karl W et al. (2017) Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster. Elife 6: |
| Lai, Ashton C; Toure, Momar; Hellerschmied, Doris et al. (2016) Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl 55:807-10 |
| Huang, David; Schuppe, Alexander W; Liang, Michael Z et al. (2016) Scalable procedure for the fragmentation of hydroperoxides mediated by copper and iron tetrafluoroborate salts. Org Biomol Chem 14:6197-200 |
| Melo, Ana M; Coraor, Juliana; Alpha-Cobb, Garrett et al. (2016) A functional role for intrinsic disorder in the tau-tubulin complex. Proc Natl Acad Sci U S A 113:14336-14341 |
| Powell, John T; Akhuetie-Oni, Benjamin O; Zhang, Zhao et al. (2016) DNA Origami Rotaxanes: Tailored Synthesis and Controlled Structure Switching. Angew Chem Int Ed Engl 55:11412-6 |
Showing the most recent 10 out of 31 publications
