The goal of the NIGMS-sponsored Systems and Integrative Biology (SIB) Training Program at The Ohio State University College of Medicine (OSU COM) is to educate an elite set of graduate students in the research approaches and competencies required for interdisciplinary basic and translational research. The Program explores mechanisms of cellular and complex organ systems, how their disruption leads to disease, and how the integration of disciplinary approaches in basic and medical sciences can lead to new discoveries that impact human health. It is coordinated with the broader COM effort within our medical center to generate discoveries that improve people?s lives through innovation in education and research. Our objective is to provide predoctoral trainees with an interdisciplinary curriculum that maintains high standards of intellectual rigor, fosters creativity and passion for research, and provides research opportunities with selected faculty that cross traditional disciplinary boundaries. The SIB Program was designed as an integral component of the larger Biomedical Sciences Graduate Program (BSGP), our parent Ph.D. training program, that provides high quality training opportunities to prepare our BSGP and MSTP graduates for successful careers in biomedical research. We are requesting funds for training six SIB predoctoral students per year for years 1 and 2 and eight SIB trainees per year for years 3-5, including three newly chosen trainees who have completed their first year in the BSGP core curriculum and three trainees who have completed one year in the SIB Program and compete for a one year renewal. Institutional support is provided. Coursework in analytics, workshops in team? building and communications skills, seminars, grant writing, training in the responsible conduct of research, and focus in two or more of eleven areas-of-research emphasis with vetted faculty members are the mechanisms by which the SIB Program provides collaborative and interdisciplinary training opportunities. The SIB Program faculty lead biomedical science research teams who are committed to student education and training, and who embrace the vision of diversity and cooperation in our academic research community. We are also committed to maintaining geographic and ethnic diversity in our Program through targeted recruitment and retention. In summary, the SIB Program will impart the interdisciplinary knowledge and skills to enable trainees to embrace our research mission and position themselves as leaders in a wide range of biomedical science careers.

Public Health Relevance

The SIB Training Program is a flagship graduate opportunity for exceptional students within the OSU COM Biomedical Sciences Graduate Program that trains students to use interdisciplinary approaches to investigate human diseases. Our goal is to generate scientists that integrate multiple biomedical science disciplines to solve complex biological problems and make discoveries to improve human health.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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NIGMS Initial Review Group (TWD)
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Nie, Zhongzhen
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Ohio State University
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United States
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McMichael, Temet M; Zhang, Yu; Kenney, Adam D et al. (2018) IFITM3 Restricts Human Metapneumovirus Infection. J Infect Dis 218:1582-1591
Chen, Hui-Zi; Bonneville, Russell; Roychowdhury, Sameek (2018) Implementing precision cancer medicine in the genomic era. Semin Cancer Biol :
Pestrak, Matthew J; Chaney, Sarah B; Eggleston, Heather C et al. (2018) Pseudomonas aeruginosa rugose small-colony variants evade host clearance, are hyper-inflammatory, and persist in multiple host environments. PLoS Pathog 14:e1006842
Cosgrove, Casey M; Tritchler, David L; Cohn, David E et al. (2018) An NRG Oncology/GOG study of molecular classification for risk prediction in endometrioid endometrial cancer. Gynecol Oncol 148:174-180
Sprague, Leslee; Braidwood, Lynne; Conner, Joe et al. (2018) Please stand by: how oncolytic viruses impact bystander cells. Future Virol 13:671-680
Olaverria Salavaggione, Gonzalo N; Duggan, Megan C; Carson, William E (2018) Analysis of MLN4924 (pevonedistat) as a potential therapeutic agent in malignant melanoma. Melanoma Res 28:390-397
Killian, Jackson A; Topiwala, Taha M; Pelletier, Alex R et al. (2018) FuSpot: a web-based tool for visual evaluation of fusion candidates. BMC Genomics 19:139
Moliva, J I; Hossfeld, A P; Canan, C H et al. (2018) Exposure to human alveolar lining fluid enhances Mycobacterium bovis BCG vaccine efficacy against Mycobacterium tuberculosis infection in a CD8+ T-cell-dependent manner. Mucosal Immunol 11:968-978
Neff, Robert; Rush, Craig M; Smith, Blair et al. (2018) Functional characterization of recurrent FOXA2 mutations seen in endometrial cancers. Int J Cancer 143:2955-2961
Ozer, Hatice Gulcin; El-Gamal, Dalia; Powell, Ben et al. (2018) BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. Cancer Discov 8:458-477

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