This program prepares scientists for research careers in the computational and mathematical modeling of medically significant biological systems through interdisciplinary training at the predoctoral level. Noted for its well-established system f interdisciplinary graduate programs and for its tradition of collaborations across departmental boundaries, the University of Arizona provides a highly suitable environment for such training. Eighteen training faculty and three associate faculty with appointments in multiple departments and interdisciplinary graduate programs provide strength in five broad areas: bioinformatics; molecular dynamics; cellular processes; physiology and pathophysiology; biostatistics and stochastic processes. Students are drawn from multiple graduate programs in mathematical and life sciences, including the interdisciplinary Graduate Program in Applied Mathematics. In most cases, students receive two years of support from this program, starting in their second or third year of graduate training. Trainees pursue the coursework requirements of their own graduate programs and, in addition, take graduate courses in mathematical modeling and in bioinformatics, which are tailored to the trainees' needs and take into account their diverse scientific backgrounds. All trainees take part in a weekly biomathematics colloquium that has been running continuously for more than fifteen years. This colloquium includes presentations by students, faculty and visiting speakers, and promotes dialog between trainees and faculty with primarily mathematical or computational backgrounds and those with strong biological training. Trainees carry out their doctoral research with advisors whose research, whether theoretical or experimental, emphasizes application of theoretical approaches to biomedical problems. Where appropriate, a co-advisor is appointed to provide complementary expertise to that of the primary advisor. Trainees participating in this program not only receive research training in relevant areas, but, equally importantly, develop the ability to communicate and collaborate across traditional disciplinary boundaries and to work with researchers with complementary expertise. Researchers with such skills are critically needed in many areas of biomedical science in which sophisticated theoretical approaches are necessary in order to achieve further progress.

Public Health Relevance

In many areas of biomedical science, quantitative theoretical approaches are necessary in order to understand complex biological systems. This program prepares scientists for research careers in the computational and mathematical modeling of medically significant biological systems through interdisciplinary training at the predoctoral leve. Trainees receive training in relevant research areas and develop the ability to collaborate across traditional disciplinary boundaries with researchers with complementary expertise.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM084905-07
Application #
8860189
Study Section
Training and Workforce Development Subcommittee - D (TWD)
Program Officer
Marcus, Stephen
Project Start
2008-07-01
Project End
2019-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
7
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Arizona
Department
Physiology
Type
Schools of Medicine
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Dawson, Peter; Romanowski, Marek (2018) Excitation Modulation of Upconversion Nanoparticles for Switch-like Control of Ultraviolet Luminescence. J Am Chem Soc 140:5714-5718
Hanschen, Erik R; Herron, Matthew D; Wiens, John J et al. (2018) Repeated evolution and reversibility of self-fertilization in the volvocine green algae. Evolution 72:386-398
Bertram, J; Gomez, K; Masel, J (2017) Predicting patterns of long-term adaptation and extinction with population genetics. Evolution 71:204-214
Wang, Xia; Fujimaki, Kotaro; Mitchell, Geoffrey C et al. (2017) Exit from quiescence displays a memory of cell growth and division. Nat Commun 8:321
Grochau-Wright, Z I; Hanschen, E R; Ferris, P J et al. (2017) Genetic basis for soma is present in undifferentiated volvocine green algae. J Evol Biol 30:1205-1218
Smith, Shane P; Secomb, Timothy W; Hong, Brian D et al. (2016) Time-Dependent Regional Myocardial Strains in Patients with Heart Failure with a Preserved Ejection Fraction. Biomed Res Int 2016:8957307
Williams, Michael R; Lehman, Sarah J; Tardiff, Jil C et al. (2016) Atomic resolution probe for allostery in the regulatory thin filament. Proc Natl Acad Sci U S A 113:3257-62
Hanschen, Erik R; Marriage, Tara N; Ferris, Patrick J et al. (2016) The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity. Nat Commun 7:11370
Vig, Dhruv K; Hamby, Alex E; Wolgemuth, Charles W (2016) On the Quantification of Cellular Velocity Fields. Biophys J 110:1469-1475
Li, Frank; Buck, Danielle; De Winter, Josine et al. (2015) Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy. Hum Mol Genet 24:5219-33

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